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Polymeric Micelles for Targeted Drug Delivery System

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Abstract

Targeted drug transport is becoming more and more popular for increasing the efficiency of interactions between a drug and a target. This method allows the drug concentration to be increased at a desired site and to block or strongly limit drug accumulation in healthy organs and tissues. Micelle-based nanopreparations can be considered as a system with unique characteristics compared to other nanocarriers, since the smaller size allows passive targeting of target organs (even poorly permeable ones) and efficient internalization by cells. Polymeric micelles are increasingly being used to create drug delivery systems. This paper presents a brief overview of the production of polymeric micelles, the release of the drug, and the possibility of their practical application.

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Funding

The study was financially supported by the Russian Science Foundation, project no. 19-14-00077-II.

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Authors and Affiliations

  1. Institute of Biochemistry and Physiology of Plants and Microorganisms, Research Institution Saratov Federal Scientific Center, Russian Academy of Sciences (IBPPM RAS), 410049, Saratov, Russia

    O. I. Guliy, S. A. Staroverov, A. S. Fomin & L. A. Dykman

  2. Saratov State Agrarian University, 410003, Saratov, Russia

    S. A. Staroverov, E. G. Zhnichkova, S. V. Kozlov & L. G. Lovtsova

Authors
  1. O. I. Guliy
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  2. S. A. Staroverov
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  3. A. S. Fomin
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  4. E. G. Zhnichkova
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  5. S. V. Kozlov
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  6. L. G. Lovtsova
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  7. L. A. Dykman
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Correspondence to O. I. Guliy.

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The authors declare that they have no conflicts of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.

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Translated by V. Mittova

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Guliy, O.I., Staroverov, S.A., Fomin, A.S. et al. Polymeric Micelles for Targeted Drug Delivery System. Appl Biochem Microbiol 58, 726–737 (2022). https://doi.org/10.1134/S0003683822060059

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  • DOI: https://doi.org/10.1134/S0003683822060059

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