Abstract
Gas chromatography was used to study changes in the fatty-acid (FA) profile of the liver and brain lipids in six groups of mice that received nanoliposomal complexes of different compositions added to drinks that replaced water in a long-term diet (3 months). The components of the six nanoliposomal types included clove essential oil (CEO), fish oil (FO), and sodium caseinate (Na-Cas), along with phosphatidylcholine (PC). It was found that compound nanoliposomal complexes that contain both essential polyunsaturated free fatty acids (PUFAs) and CEO natural antioxidant, along with Na-Cas food protein, can modify the liver and brain lipid profiles and increase the amount of decosahexaenoic acid (DHA) while considerably reducing the Σ omega-6/Σ omega-3 PUFA ratio. Such changes may increase resistance to inflammatory processes and reduce the risk of cancer and neuropsychiatric diseases. The obtained data may be used to develop new PUFA delivery systems based on PC liposomes.
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The study was conducted as State Assignment no. 1201253307.
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Statement on the welfare of animals. The studies were conducted in compliance with the principles of Good Laboratory Practices of the Russian Federation and according to the rules adopted by European Convention for the Protection of Vertebrate Animals Used for Experimental and other Scientific Purposes (ETS 123), Strasburg, 1986, in compliance with the written protocol and in accordance with the standard operating procedures (SOPs) and Guidance on Laboratory Animals and Alternative Models in Biomedical Technologies. The experiments did not involve human subjects.
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Palmina, N.P., Misharina, T.A., Krikunova, N.I. et al. Changes in the Free Fatty-Acid Profile in the Liver and Brain of Mice Receiving Nanolipid Complexes. Appl Biochem Microbiol 57, 250–256 (2021). https://doi.org/10.1134/S0003683821020101
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DOI: https://doi.org/10.1134/S0003683821020101