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Synthesis, chemical structure elucidation, and biological studies on the effect of some vital metal ions on sulfadoxine

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Abstract

Complexes of sulfadoxine as a pharmaceutical ligand with Ca(II), Mg(II), Zn(II), Fe(III), and VO(II), were synthesized and characterized by microanalysis, conductance, infrared and thermogravimetric (TGA/DTG and DTA) measurements. The ligand can be coordinate as a bidentate feature via (C=N) and (S=O) groups. Sulfadoxine ligand as well as their complexes has been checked against some kinds of bacteria and fungi which gave a significant effect. The kinetic thermodynamic parameters such as: activation of E*, ΔH*, ΔS*, and ΔG* were estimated using Coats-Redfern as well as Horowitz-Metzger equations.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt

    M. Zaky, Mohamed Y. El-Sayed, Samy M. El-Megharbel & Sameh Abo Taleb

  2. Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt

    Moamen S. Refat

  3. Department of Chemistry, Faculty of Science, Taif University, Taif, 888, Kingdom Saudi Arabia

    Samy M. El-Megharbel & Moamen S. Refat

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  1. M. Zaky
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  2. Mohamed Y. El-Sayed
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  3. Samy M. El-Megharbel
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  4. Sameh Abo Taleb
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  5. Moamen S. Refat
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Correspondence to Moamen S. Refat.

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Zaky, M., El-Sayed, M.Y., El-Megharbel, S.M. et al. Synthesis, chemical structure elucidation, and biological studies on the effect of some vital metal ions on sulfadoxine. Russ J Gen Chem 85, 176–184 (2015). https://doi.org/10.1134/S1070363215010314

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  • DOI: https://doi.org/10.1134/S1070363215010314

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