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Nanomaterials and nanoparticles: Sources and toxicity

Biointerphases volume 2, pages MR17–MR71 (2007)Cite this article

Abstract

This review is presented as a common foundation for scientists interested in nanoparticles, their origin, activity, and biological toxicity. It is written with the goal of rationalizing and informing public health concerns related to this sometimes-strange new science of “nano,” while raising awareness of nanomaterials’ toxicity among scientists and manufacturers handling them. We show that humans have always been exposed to tiny particles via dust storms, volcanic ash, and other natural processes, and that our bodily systems are well adapted to protect us from these potentially harmful intruders. The reticuloendothelial system, in particular, actively neutralizes and eliminates foreign matter in the body, including viruses and nonbiological particles. Particles originating from human activities have existed for millennia, e.g., smoke from combustion and lint from garments, but the recent development of industry and combustion-based engine transportation has profoundly increased anthropogenic particulate pollution. Significantly, technological advancement has also changed the character of particulate pollution, increasing the proportion of nanometer-sized particles-“nanoparticles”-and expanding the variety of chemical compositions. Recent epidemiological studies have shown a strong correlation between particulate air pollution levels, respiratory and cardiovascular diseases, various cancers, and mortality. Adverse effects of nanoparticles on human health depend on individual factors such as genetics and existing disease, as well as exposure, and nanoparticle chemistry, size, shape, agglomeration state, and electromagnetic properties. Animal and human studies show that inhaled nanoparticles are less efficiently removed than larger particles by the macrophage clearance mechanisms in the lungs, causing lung damage, and that nanoparticles can translocate through the circulatory, lymphatic, and nervous systems to many tissues and organs, including the brain. The key to understanding the toxicity of nanoparticles is that their minute size, smaller than cells and cellular organelles, allows them to penetrate these basic biological structures, disrupting their normal function. Examples of toxic effects include tissue inflammation, and altered cellular redox balance toward oxidation, causing abnormal function or cell death. The manipulation of matter at the scale of atoms, “nanotechnology,” is creating many new materials with characteristics not always easily predicted from current knowledge. Within the nearly limitless diversity of these materials, some happen to be toxic to biological systems, others are relatively benign, while others confer health benefits. Some of these materials have desirable characteristics for industrial applications, as nanostructured materials often exhibit beneficial properties, from UV absorbance in sunscreen to oil-less lubrication of motors. A rational science-based approach is needed to minimize harm caused by these materials, while supporting continued study and appropriate industrial development. As current knowledge of the toxicology of “bulk” materials may not suffice in reliably predicting toxic forms of nanoparticles, ongoing and expanded study of “nanotoxicity” will be necessary. For nanotechnologies with clearly associated health risks, intelligent design of materials and devices is needed to derive the benefits of these new technologies while limiting adverse health impacts. Human exposure to toxic nanoparticles can be reduced through identifying creation-exposure pathways of toxins, a study that may someday soon unravel the mysteries of diseases such as Parkinson’s and Alzheimer’s. Reduction in fossil fuel combustion would have a large impact on global human exposure to nanoparticles, as would limiting deforestation and desertification. While nanotoxicity is a relatively new concept to science, this review reveals the result of life’s long history of evolution in the presence of nanoparticles, and how the human body, in particular, has adapted to defend itself against nanoparticulate intruders.

Abbreviations

μm:

micrometer

1D:

One Dimensional

2D:

Two Dimensional

3D:

Three Dimensional

AFM:

Atomic Force Microscopy

AQI:

Air Quality Index

CNTs:

Carbon NanoTubes

DNA:

DeoxyriboNucleic Acid

EDS:

Energy Dispersive Spectrometry

EPA:

Environmental Protection Agency

GLAD:

Glancing Angle Deposition

HIV:

Human Immunodeficiency Virus

MISR:

Multi-angle Imaging SpectroRadiometer

MODIS:

MODerate-resolution Imaging Spectroradiometer

MWCNTs:

Multiple-Wall Carbon NanoTubes

NASA:

National Aeronautics and Space Administration

nm:

nanometer

PM:

Particulate Matter

ROS:

Reactive Oxygen Species

SEM:

Scanning Electron Microscopy

SWCNs:

Single-Wall Carbon Nanotubes

TEM:

Transmission Electron Microscope

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  1. Cristina Buzea

    Present address: Department of Physics, Queen’s University, K7L 3N6, Kingston, Ontario, Canada

Authors and Affiliations

  1. Department of Physics, Queen’s University, K7L 3N6, Kingston, Ontario, Canada

    Kevin Robbie

  2. Gastrointestinal Diseases Research Unit and Department of Physiology, Queen’s University at Kingston General Hospital, 76 Stuart St., K7L 2V7, Kingston, Ontario, Canada

    Ivan I. Pacheco

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  1. Cristina Buzea
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Buzea, C., Pacheco, I.I. & Robbie, K. Nanomaterials and nanoparticles: Sources and toxicity. Biointerphases 2, MR17–MR71 (2007). https://doi.org/10.1116/1.2815690

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