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Airborne Nanostructured Particles and Occupational Health

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Abstract

Nanotechnology is leading to the development in many field, of new materials and devices in many fields that demonstrate nanostructure-dependent properties. However, concern has been expressed that these same properties may present unique challenges to addressing potential health impact. Airborne particles associated with engineered nanomaterials are of particular concern, as they can readily enter the body through inhalation. Research into the potential occupational health risks associated with inhaling engineered nanostructured particles is just beginning. However, there is a large body of data on occupational and environmental aerosols, which is applicable to developing an initial assessment of potential risk and risk reduction strategies. Epidemiological and pathological studies of occupational and environmental exposures to airborne particles and fibers provide information on the aerosol-related lung diseases and conditions that have been observed in humans. Toxicological studies provide information on the specific disease mechanisms, dose–response relationships, and the particle characteristics that influence toxicity, including the size, surface area, chemistry or reactivity, solubility, and shape. Potential health risk will depend on the magnitude and nature of exposures to airborne nanostructured particles, and on the release, dispersion, transformation and control of materials in the workplace. Aerosol control methods have not been well-characterized for nanometer diameter particles, although theory and limited experimental data indicate that conventional ventilation, engineering control and filtration approaches should be applicable in many situations. Current information supports the development of preliminary guiding principles on working with engineered nanomaterials. However critical research questions remain to be answered before the potential health risk of airborne nanostructured particles in the workplace can be fully addressed.

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References

  • InstitutionalAuthorNameACGIH (2001) Industrial Ventilation: A Manual of Recommended Practice Cincinnati OH, ACGIH

    Google Scholar 

  • R.J. Aitken K.S. Creely C.L. Tran (2004) Nanoparticles: An Occupational Hygiene Review Institute of Occupational Medicine Edinburgh, UK

    Google Scholar 

  • J.M. Antonini (2003) ArticleTitleHealth effects of welding Crit. Rev. Toxicol. 33 IssueID1 61–103 Occurrence Handle1:CAS:528:DC%2BD3sXmvFShuro%3D

    CAS  Google Scholar 

  • M.D. Attfield J. Costello (2004) ArticleTitleQuantitative exposure-response for silica dust and lung cancer in Vermont granite workers Am. J. Ind. Med. 45 129–138 Occurrence Handle10.1002/ajim.10348 Occurrence Handle1:CAS:528:DC%2BD2cXitVKrt70%3D

    Article  CAS  Google Scholar 

  • M.D. Attfield N.S. Seixas (1995) ArticleTitlePrevalence of pneumoconiosis and its relationship to dust exposure in a cohort of U.S. bituminous coal miners and ex-miners Am. J. Ind. Med. 27 137–151 Occurrence Handle1:STN:280:DyaK2M3gvVKktA%3D%3D

    CAS  Google Scholar 

  • Balazy A., A. Podgórski & L. Grado, 2004. Filtration of nanosized aerosol particles in fibrous filters: I – Experimental results. European Aerosol Conference 2004

  • U. Baltensperger H.W. Gaggeler D.T. Jost (1988) ArticleTitleThe Epiphaniometer, a new device for continuous aerosol monitoring J. Aerosol Sci. 19 IssueID7 931–934 Occurrence Handle1:CAS:528:DyaL1MXht1Sgs7Y%3D

    CAS  Google Scholar 

  • U. Baltensperger S. Nyeki (1998) Atmospheric aerosols I. Colbeck (Eds) Physical and Chemical Properties of Aerosols I. Colbeck, Ed., Blackie Academic & Professional London 280–330

    Google Scholar 

  • I. Balásházy W. Hofmann (2000) ArticleTitleQuantification of local deposition patterns of inhaled radon decay products in human bronchial airway bifurcations Health Phys. 78 IssueID2 147–158

    Google Scholar 

  • I. Balásházy W. Hofmann T. Heistracher (2003) ArticleTitleLocal particle deposition patterns may play a key role in the development of lung cancer J. Appl. Physiol. 94 1719–1725

    Google Scholar 

  • Baron P.A., A.D. Maynard & M. Foley, 2003. Evaluation of aerosol release during the handling of unrefined carbon nanotube material, DART-02-191/NTIS PB2003-102401 Cincinnati, OH, NIOSH

  • P.A. Baron C.M. Sorensen J.E. Brockmann (2001) Nonspherical particle measurements: Shape factors, fractals and fibers P.A. Baron K. Willeke (Eds) Aerosol Measurement. Principles, Techniques and Applications EditionNumber2 Wiley Interscience New York 705–749

    Google Scholar 

  • Bedford T. & C. Warner, 1943. Physical studies of the dust hazard and thermal environment in certain coalmines. Chronic Pulmonary Disease in South Wales Coalminers. II. Environmental Studies. London, British Medical Research Council, HMSO. Special report series no. 244, 1–78

  • P. Boffetta A. Soutar J.W. Cherrie F. Granath A. Andersen A. Anttila M. Blettner V. Gaborieau S.J. Klug S. Langard D. Luce F. Merletti B. Miller D. Mirabelli E. Pukkala H.-O. Adami E. Weiderpass (2004) ArticleTitleMortality among workers employed in the titanium dioxide production industry in Europe Cancer Cause Control 15 IssueID7 697–706

    Google Scholar 

  • D.H. Brouwer J.H.J. Gijsbers M.W.M. Lurvink (2004) ArticleTitlePersonal exposure to ultrafine particles in the workplace: Exploring sampling techniques and strategies Ann. Occup. Hyg. 48 IssueID5 439–453 Occurrence Handle1:CAS:528:DC%2BD2cXntV2rtLc%3D

    CAS  Google Scholar 

  • D.M. Brown M.R. Wilson W. MacNee V. Stone K. Donaldson (2001) ArticleTitleSize-dependent proinflammatory effects of ultrafine polystyrene particles: A role for surface area and oxidative stress in the enhanced activity of ultrafines Toxicol. Appl. Pharmacol. 175 IssueID3 191–199 Occurrence Handle10.1006/taap.2001.9240 Occurrence Handle1:CAS:528:DC%2BD3MXmsl2nu7o%3D

    Article  CAS  Google Scholar 

  • J.S. Brown K.L. Zeman W.D. Bennett (2002) ArticleTitleUltrafine particle deposition and clearance in the healthy and obstructed lung Am. J. Respir. Crit. Care Med. 166 1240–1247 Occurrence Handle10.1164/rccm.200205-399OC

    Article  Google Scholar 

  • L.M. Brown N. Collings R.M. Harrison A.D. Maynard R.L. Maynard (Eds) (2003) Ultrafine Particles in the Atmosphere Imperial College Press 350 London, UK

    Google Scholar 

  • R.C. Brown (1993) Air Filtration. An Integrated Approach to the Theory and Applications of Fibrous Filters Pergamon Press Oxford

    Google Scholar 

  • R.E. Brubaker (1977) ArticleTitlePulmonary problems associated with the use of polytetrafluoroethylene (PTFE) J. Occup. Med. 19 693–695 Occurrence Handle1:STN:280:DyaE1c%2FgslCjuw%3D%3D

    CAS  Google Scholar 

  • S. Brunauer P.H. Emmett E. Teller (1938) ArticleTitleAdsorption of gases in multimolecular layers J. Am. Chem. Soc. 60 309 Occurrence Handle10.1021/ja01269a023 Occurrence Handle1:CAS:528:DyaA1cXivFaruw%3D%3D

    Article  CAS  Google Scholar 

  • P. Calvert (1992) ArticleTitleStrength in disunity Nature 357 365–366 Occurrence Handle10.1038/357365a0

    Article  Google Scholar 

  • P. Camus B. Nemery (1998) ArticleTitleA novel cause for bronchioltis obliterans organizing pneumonia: Exposure to paint aerosols in textile workshops Eur. Repir. J. 11 259–262 Occurrence Handle1:STN:280:DyaK1c3htFCntw%3D%3D

    CAS  Google Scholar 

  • G.R. Cass L.A. Hughes P.V. Bhave M.J. Kleeman J.O. Allen L.G. Salmon (2000) ArticleTitleThe chemical composition of atmospheric ultrafine particles Philos. Trans. Roy. Soc. Lond. a – Math. Phys. Eng. Sci. 358 IssueID1775 2581–2592 Occurrence Handle1:CAS:528:DC%2BD3cXoslWju7s%3D

    CAS  Google Scholar 

  • V. Castranova (1998) ArticleTitleParticles and the airways: Basic biological mechanisms of pulmonary pathogenicity Appl. Occup. Environ. Hyg. 13 IssueID8 613–616 Occurrence Handle1:CAS:528:DyaK1cXlvFeisL0%3D

    CAS  Google Scholar 

  • V. Castranova (2000) ArticleTitleFrom coal mine dust to quartz: Mechanisms of pulmonary pathogenicity Inhal. Tox. 12 IssueIDSuppl. 3 7–14 Occurrence Handle1:CAS:528:DC%2BD3cXntlCgu7c%3D

    CAS  Google Scholar 

  • V. Castranova V. Vallyathan (2000) ArticleTitleSilicosis and coal workers’ pneumoconiosis Environ. Health Perspect. 108 IssueIDSuppl. 4 675–684 Occurrence Handle1:CAS:528:DC%2BD3cXms1yls7Y%3D

    CAS  Google Scholar 

  • D.C. Chalupa P.E. Morrow G. Oberdorster M.J. Utell M.W. Frampton (2004) ArticleTitleUltrafine particle deposition in subjects with asthma Environ. Health Perspect. 112 IssueID8 879–882 Occurrence Handle1:CAS:528:DC%2BD2cXlvFSns7c%3D Occurrence Handle10.1289/ehp.6851

    Article  CAS  Google Scholar 

  • Y.-S. Cheng (2001) Condensation detection and diffusion size separation techniques P.A. Baron K. Willeke (Eds) Aerosol Measurement Principles, Techniques and Applications John Wiley & Sons New York 569–601

    Google Scholar 

  • M. Choi P. Biswas H. Fissan D.H.Y. Pui (2003) ArticleTitleNanoparticles and the environment. Part 1. Focus on nanoparticles: Technology and sustainable development J. Nanoparticle Res. 5 IssueID3–4 181–321

    Google Scholar 

  • A. Churg M. Brauer M. Carmen Avila-Casado Particledel T.I. Fortoul J.L. Wright (2003) ArticleTitleChronic exposure to high levels of particulate air pollution and small airway remodeling Environ. Health Perspect. 111 IssueID5 714–718 Occurrence Handle1:CAS:528:DC%2BD3sXktlequrc%3D

    CAS  Google Scholar 

  • A. Churg S. Vedal (1996) ArticleTitleCarinal and tubular airway particle concentrations in the large airways of non-smokers in the general population: Evidence for high particle concentration at airway carinas Occup. Environ. Med. 53 553–558 Occurrence Handle1:STN:280:DyaK2s7gsFamsQ%3D%3D Occurrence Handle10.1136/oem.53.8.553

    Article  CAS  Google Scholar 

  • InstitutionalAuthorNameCIIT and RIVM (2002) Multiple-path model of particle deposition (MPPD V. 10) Centers for Health Research (CIIT) Research Triangle Park; NC

    Google Scholar 

  • National Institute for Public Health and the Environment (RIVM); The Netherlands

  • G.V. Coles (1992) ArticleTitleOccupational risks Nature 359 399 Occurrence Handle10.1038/359099b0

    Article  Google Scholar 

  • M. Costa Z. Zhuang X. Huang S. Cosentino C.B. Klein K. Salnikow (1994) ArticleTitleMolecular mechanisms of nickel carcinogenesis Sci. Total Environ. 148 191–199 Occurrence Handle10.1016/0048-9697(94)90396-4 Occurrence Handle1:CAS:528:DyaK2cXkslGqsrg%3D

    Article  CAS  Google Scholar 

  • C.C. Daigle D.C. Chalupa F.R. Gibb P.E. Morrow G. Oberdorster M.J. Utell M.W. Frampton (2003) ArticleTitleUltrafine particle deposition in humans during rest and exercise Inhal. Toxicol. 15 IssueID6 539–552 Occurrence Handle1:CAS:528:DC%2BD3sXivFGquro%3D

    CAS  Google Scholar 

  • F. Daroowalla M.-L. Wang C. Piacitelli M.D. Attfield K. Kreiss (2005) ArticleTitleFlock workers’ exposures and respiratory symptoms in five plants Am. J. Ind. Med. 47 IssueID2 144–152 Occurrence Handle10.1002/ajim.20120

    Article  Google Scholar 

  • C.A.J. Dick D.M. Brown K. Donaldson V. Stone (2003) ArticleTitleThe role of free radicals in the toxic and inflammatory effects of four different ultrafine particle types Inhal. Toxicol. 15 IssueID1 39–52 Occurrence Handle1:CAS:528:DC%2BD38XpslGlsL4%3D

    CAS  Google Scholar 

  • D.W. Dockery C.A. Pope X. Xu J.D. Spengler J.H. Ware M.E. Fay B.G. Ferris F.E. Speizer (1993) ArticleTitleAn association between air pollution and mortality in six U.S. cities N. Engl. J. Med 329 IssueID24 1753–1759 Occurrence Handle10.1056/NEJM199312093292401 Occurrence Handle1:STN:280:DyaK2c%2FltVSmtQ%3D%3D

    Article  CAS  Google Scholar 

  • InstitutionalAuthorNameDOE (1998) DOE HEPA filter test program U. D. o. Energy US Department of Commerce Technology Administration Springfield

    Google Scholar 

  • R. Doll (1955) ArticleTitleMortality from lung cancer in asbestos workers Br. J. Ind. Med. 12 81–86 Occurrence Handle1:CAS:528:DyaG2MXkslensQ%3D%3D

    CAS  Google Scholar 

  • K. Donaldson X.Y. Li W. MacNee (1998) ArticleTitleUltrafine (nanometer) particle mediated lung injury J. Aerosol Sci. 29 IssueID5–6 553–560 Occurrence Handle1:CAS:528:DyaK1cXjslygtLc%3D

    CAS  Google Scholar 

  • K. Donaldson V. Stone (2003) ArticleTitleCurrent hypotheses on the mechanisms of toxicity of ultrafine particles Ann 1st Super Sanità 39 IssueID3 405–410 Occurrence Handle1:CAS:528:DC%2BD2cXhvFahsbk%3D

    CAS  Google Scholar 

  • K. Donaldson V. Stone P.S. Gilmore D.M. Brown W. MacNee (2000) ArticleTitleUltrafine particles: Mechanisms of lung injury Philos. Trans. Roy. Soc. Lond. A 358 2741–2749 Occurrence Handle1:CAS:528:DC%2BD3cXoslWisrg%3D

    CAS  Google Scholar 

  • K. Donaldson V. Stone A. Seaton W. MacNee (2001) ArticleTitleAmbient particle inhalation and the cardiovascular system: Potential mechanisms Environ. Health Perspect. 109 523–527 Occurrence Handle1:CAS:528:DC%2BD3MXmvVagt7c%3D

    CAS  Google Scholar 

  • K. Donaldson V. Stone C.L. Tran W. Kreyling P.J.A. Borm (2004) ArticleTitleNanotoxicology Occup. Environ. Med. 61 727–728 Occurrence Handle10.1136/oem.2004.013243 Occurrence Handle1:STN:280:DC%2BD2cvhtlGlsQ%3D%3D

    Article  CAS  Google Scholar 

  • K.L. Dreher (2000) ArticleTitleParticulate matter physicochemistry and toxicology: In search of causality – a critical perspective Inhalat. Toxicol. 12 45–57 Occurrence Handle1:CAS:528:DC%2BD3cXntlCnsr0%3D

    CAS  Google Scholar 

  • K.E. Driscoll (1996) Role of inflammation in the development of rat lung tumors in response to chronic particle exposure J. L. Mauderly R.J. McCunney (Eds) Particle Overload in the Rat Lung and Lung Cancer: Implications for Human Risk Assessment Taylor & Francis Philadelphia, PA 139–152

    Google Scholar 

  • R. Duffin C.L. Tran A. Clouter D.M. Brown W. MacNee V. Stone K. Donaldson (2002) ArticleTitleThe importance of surface area and specific reactivity in the acute pulmonary inflammatory response to particles Ann. Occup. Hyg. 46 242–245

    Google Scholar 

  • J.K. Dunnick M.R. Elwell A.E. Radovsky J.M. Benson F.F. Hahn K.J. Nikula E.B. Barr C.H. Hobbs (1995) ArticleTitleComparative carcinogenic effects of nickel subsulfide, nickel oxide, or nickel sulfate hexahydrate chronic exposures in the lung Cancer Res. 55 5251–5256 Occurrence Handle1:CAS:528:DyaK2MXpsVaru7s%3D

    CAS  Google Scholar 

  • ETC Group, 2003. No Small Matter II: The Case for a Global Moratorium. Size Matters! Occasional Paper Series Vol. 7, No. 1 Winnipeg, Canada, ETC Group

  • E.A. Evans (1973) ArticleTitlePulmonary edema after inhalation of fumes from polytetrafluoroethylene (PTFE) J. Occup. Med. 15 599–601 Occurrence Handle1:STN:280:DyaE3s7pslykuw%3D%3D

    CAS  Google Scholar 

  • J. Ferin G. Oberdörster (1992) ArticleTitleTranslocation of particles from pulmonary alveoli into the interstitium J. Aerosol Med.-Deposit. Clear. Effects Lung 5 IssueID3 179–187

    Google Scholar 

  • J. Ferin G. Oberdörster S.C. Soderholm R. Gelein (1991) ArticleTitlePulmonary tissue access of ultrafine particles J. Aerosol Med.-Deposit. Clear. Effects Lung 4 IssueID1 57–68

    Google Scholar 

  • R.C. Flagan (2004) ArticleTitleOpposed Migration Aerosol Classifier (OMAC) Aerosol Sci. Technol. 38 IssueID9 890–899 Occurrence Handle10.1080/027868290505242 Occurrence Handle1:CAS:528:DC%2BD2cXntlequr4%3D

    Article  CAS  Google Scholar 

  • Friedlander S.K. & D.Y.H. Pui, 2004. Emerging Issues in Nanoparticle Aerosol Science and Technology (NAST), NSF Workshop Report, NSF

  • J.P. Fryzek B. Chadda D. Marano K. White S. Schweitzer J.K. McLaughlin W.J. Blot (2003) ArticleTitleA cohort mortality study among titanium dioxide manufacturing workers in the United States J. Occup. Environ. Med. 45 400–409 Occurrence Handle1:CAS:528:DC%2BD3sXitl2hsLw%3D

    CAS  Google Scholar 

  • B. Fubini (1998) ArticleTitleSurface chemistry and quartz hazard Ann. Occup. Hyg. 42 521–530 Occurrence Handle10.1016/S0003-4878(98)00066-0 Occurrence Handle1:CAS:528:DyaK1cXnvFyis7o%3D

    Article  CAS  Google Scholar 

  • N.A. Fuchs (1964) The Mechanics of Aerosols Pergamon Oxford

    Google Scholar 

  • K. Gardiner M. Tongeren Particlevan M. Harrington (2001) ArticleTitleRespiratory health effects from exposure to carbon black: Results of the phase 2 and 3 cross sectional studies in the European carbon black manufacturing industry Occup. Environ. Med. 58 IssueID8 496–503 Occurrence Handle10.1136/oem.58.8.496 Occurrence Handle1:CAS:528:DC%2BD3MXmtVOksr8%3D

    Article  CAS  Google Scholar 

  • A.N.I. Garrod R. Rajan-Sithamparanadarajah (2003) ArticleTitleDeveloping COSHH essentials: Dermal exposure, personal protective equipment and first aid Ann. Occup. Hyg. 47 IssueID7 577–588 Occurrence Handle1:CAS:528:DC%2BD2cXitlaq

    CAS  Google Scholar 

  • E. Garshick F. Laden J.E. Hart R. Rosner T.J. Smith D.W. Dockery F.E. Speizer (2004) ArticleTitleLung cancer in railroad workers exposed to diesel exhaust Environ. Health Perspect. 112 IssueID15 1539–1543 Occurrence Handle1:CAS:528:DC%2BD2cXhtVGmur%2FK Occurrence Handle10.1289/ehp.7195

    Article  CAS  Google Scholar 

  • Green H.L. & H.H. Watson, 1935. Physical Methods for the Estimation of the Dust Hazard in Industry 119, Medical Research Council Special Report Series. London

  • H.W. Gäggeler U. Baltensperger M. Emmenegger D.T. Jost A. Schmidt-Orr P. Haller M. Hofmann (1989) ArticleTitleThe Epiphaniometer, a new device for continuous aerosol monitoring J. Aerosol Sci. 20 IssueID5 557–564

    Google Scholar 

  • R.M. Harrison J.P. Shi X. Shuhua A. Kahn D. Mark R. Kinnersley J. Yin (2000) ArticleTitleMeasurement of number, mass and size distribution of particles in the atmosphere Philos. Trans. Roy. Soc. Lond. Ser. a – Math. Phys. Eng. Sci. 358 IssueID1775 2567–2580 Occurrence Handle1:CAS:528:DC%2BD3cXoslWju7o%3D

    CAS  Google Scholar 

  • U. Heinrich R. Fuhst S. Rittinghausen O. Creutzenberg B. Bellmann W. Koch K. Levsen (1995) ArticleTitleChronic inhalation exposure of wistar rats and 2 different strains of mice to diesel-engine exhaust, carbon-black, and titanium-dioxide Inhalat. Toxicol. 7 IssueID4 533–556 Occurrence Handle1:CAS:528:DyaK2MXmsFemur0%3D

    CAS  Google Scholar 

  • W.A. Heitbrink P.A. Baron K. Willeke (1992) ArticleTitleAn investigation of dust generation by free falling powders Am. Indus. Hyg. Assoc. J. 53 IssueID10 617–624 Occurrence Handle1:CAS:528:DyaK3sXhvFOjt7c%3D

    CAS  Google Scholar 

  • W.C. Hinds (1999) Aerosol Technology: Properties, Behavior, and Measurement of airborne Particles EditionNumber2 Wiley-Interscience New York

    Google Scholar 

  • P.H. Hoet M.L. Gilissen B. Nemery (2001) ArticleTitlePolyanions protect agains the in vitro pulmonary toxicity of polycationic paint components associated with the Ardystil Syndrome Toxicol. Appl. Pharmacol. 175 184–190 Occurrence Handle10.1006/taap.2001.9247 Occurrence Handle1:CAS:528:DC%2BD3MXmsFyhsrY%3D

    Article  CAS  Google Scholar 

  • E. Hood (2004) ArticleTitleNanotechnology: Looking as we leap Environ. Health Perspect. 112 IssueID13 A741–A749 Occurrence Handle10.1289/ehp.112-a740

    Article  Google Scholar 

  • InstitutionalAuthorNameHSE (1996) MDHS 81 Dustiness of Powders and Materials Health and Safety Executive. HSE Books UK

    Google Scholar 

  • HSE, 2004a. Health effects of particles produced for nanotechnologies. UK Health and Safety Executive, Health & Safety Executive

  • HSE, 2004b. Horizon scannon information sheet on nanotechnology. UK Health and Safety Executive, UK Health and Safety Executive

  • A. Huckzko H. Lange (2001) ArticleTitleCarbon nanotubes: Experimental evidence for a null risk of skin irritation and allergy Fullerene Sci. Technol. 9 IssueID2 247–250

    Google Scholar 

  • A. Huckzko H. Lange E. Calko H. Grubeck-Jaworska P. Droszez (2001) ArticleTitlePhysiological testing of carbon nanotubes: Are they asbestos-like? Fullerene Sci. Technol. 9 IssueID2 251–254

    Google Scholar 

  • D. Hunter (1978) The Diseases of Occupations EditionNumber6 Hodder and Stoughton London

    Google Scholar 

  • J.F. Hurley W.P. Alexander D.J. Hazledine M. Jacobsen W.M. Maclaren (1987) ArticleTitleExposure to respirable coalmine dust and incidence of progressive massive fibrosis Br. J. Ind. Med. 44 661–672 Occurrence Handle1:CAS:528:DyaL2sXmsVWrsLk%3D

    CAS  Google Scholar 

  • InstitutionalAuthorNameICRP (1994) International Commission on Radiological Protection Publication 66** Human Respiratory Tract Model for Radiological Protection Elsevier Science Ltd Oxford, Pergamon

    Google Scholar 

  • ISO, 1995. Air Quality - Particle size fraction definitions for health-related sampling, ISO 7708: 1995 Geneva, International Standards Organisation

  • P.A. Jaques C.S. Kim (2000) ArticleTitleMeasurement of total lung deposition of inhaled ultrafine particles in healthy men and women Inhal. Toxicol. 12 IssueID8 715–731 Occurrence Handle1:CAS:528:DC%2BD3cXmsFKjs7c%3D

    CAS  Google Scholar 

  • A. Keller M. Fierz K. Siegmann H.C. Siegmann A. Filippov (2001) ArticleTitleSurface science with nanosized particles in a carrier gas J. Vacuum Sci. Technol. a – Vacuum Surfaces Films 19 IssueID1 1–8 Occurrence Handle1:CAS:528:DC%2BD3MXjt12hsg%3D%3D

    CAS  Google Scholar 

  • M. Kendall T.D. Tetley E. Wigzell B. Hutton M. Nieuwenhuijsen P. Luckham (2002) ArticleTitleLung lining liquid modifies PM2.5 in favor of particle aggregation: A protective mechanism Am. J. Physiol. – Lung Cell. Mol. Physiol. 282 IssueID1 L109–L114 Occurrence Handle1:CAS:528:DC%2BD38XlsVOhsQ%3D%3D

    CAS  Google Scholar 

  • U.P. Kodavanti R. Hauser D.C. Christiani Z.H. Meng J. McGee A. Ledbetter J. Reichards D.L. Costa (1998) ArticleTitlePulmonary responses to oil fly ash particles in the rat differ by virtue of their specific soluble metals Toxicol. Sci. 43 204–212 Occurrence Handle10.1006/toxs.1998.2460 Occurrence Handle1:CAS:528:DyaK1cXltVKktrY%3D

    Article  CAS  Google Scholar 

  • Kreiss K., M.M. Mroz, B. Zhen, H. Wiedemann & B. Barna, 1997. Risks of beryllium disease related to work processes at a metal, alloy, and oxide production plant. Occup. Environ Medicine. 54(8), 605–612

    Google Scholar 

  • W.G. Kreyling M. Semmler F. Erbe P. Mayer S. Takenaka H. Schulz G. Oberdorster A. Ziesenis (2002) ArticleTitleTranslocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonary organs is size dependent but very low J. Toxicol. Environ. Health Pt A 65 IssueID20 1513–1530 Occurrence Handle1:CAS:528:DC%2BD38XosF2lsbw%3D

    CAS  Google Scholar 

  • F.E. Kruis H. Fissan A. Peled (1998) ArticleTitleSynthesis of nanoparticles in the gas phase for electronic, optical and magnetic applications - A review J. Aerosol Sci. 29 IssueID5–6 511–535 Occurrence Handle1:CAS:528:DyaK1cXjslygtLk%3D

    CAS  Google Scholar 

  • Ku B.K. & A.D. Maynard, 2005. Comparing aerosol surface-area measurement of monodisperse ultrafine silver agglomerates using mobility analysis, transmission electron microscopy and diffusion charging. J. Aerosol Sci. In press Available online all www.elsevier.com

  • Kuempel E.D., M.D. Attfield, V. Vallyathan, N.L. Lapp, J.M. Hale, R.J. Smith & V. Castranova, 2003. Pulmonary inflammation and crystalline silica in respirable coal mine dust: Dose-response. J. Biosci. (28), 61--69

  • E.D. Kuempel R.J. Smith M.D. Attfield L.T. Stayner (1997) ArticleTitleRisks of occupational respiratory diseases among U.S. coal miners Appl. Occup. Environ. Hyg. 12 823–831

    Google Scholar 

  • E.D. Kuempel L.T. Stayner M.D. Attfield C.R. Buncher (1995) ArticleTitleExposure response analysis of mortality among coal miners in the United States Am. J. Ind. Med. 28 167–184 Occurrence Handle1:STN:280:DyaK287ntF2nsQ%3D%3D

    CAS  Google Scholar 

  • E.D. Kuempel C.L. Tran A.J. Bailer R.J. Smith D.A. Dankovic L.T. Stayner (2001a) ArticleTitleMethodological issues of using observational human data in lung dosimetry models for particulates Sci. Total Environ. 274 IssueID1–3 67–77 Occurrence Handle1:CAS:528:DC%2BD3MXks1ejs74%3D

    CAS  Google Scholar 

  • E.D. Kuempel C.L. Tran R.J. Smith A.J. Bailer (2001b) ArticleTitleA biomathematical model of particle clearance and retention in the lungs of coal miners – II. Evaluation of variability and uncertainty Regul. Toxicol. Pharmacol. 34 IssueID1 88–101 Occurrence Handle1:CAS:528:DC%2BD3MXlvVKrurk%3D

    CAS  Google Scholar 

  • T.A.J. Kuhlbusch S. Neumann H. Fissan (2004) ArticleTitleNumber size distribution, mass concentration, and particle composition of PM1, PM2.5, and PM10 in bag filling areas of carbon black production J. Occup. Environ. Hyg. 1 IssueID10 660–671 Occurrence Handle1:CAS:528:DC%2BD2cXmsFSltbs%3D

    CAS  Google Scholar 

  • P. Kumar P. Biswas (2005) ArticleTitleAnalytical expressions of the collision frequency function for aggregation of magnetic particles J. Aerosol Sci. 36 IssueID4 455–469 Occurrence Handle1:CAS:528:DC%2BD2MXisFyitLo%3D

    CAS  Google Scholar 

  • C.-W. Lam J.T. James R. McCluskey R.L. Hunter (2004) ArticleTitlePulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation Toxicol. Sci. 77 126–134 Occurrence Handle1:CAS:528:DC%2BD2cXnslKk

    CAS  Google Scholar 

  • G. Lasfargues C. Lardot M. Delos R. Lauwerys D. Lison (1995) ArticleTitleThe delayed lung responses to single and repeated intratracheal administration of pure cobalt and hard metal powder in the rat Environ. Res. 69 108–121 Occurrence Handle10.1006/enrs.1995.1032 Occurrence Handle1:CAS:528:DyaK28XhtV2gtrk%3D

    Article  CAS  Google Scholar 

  • K.P. Lee H.J. Trochimowicz C.F. Reinhardt (1985) ArticleTitlePulmonary response of rats exposed to titanium dioxide (TiO2) by inhalation for two years Toxicol. Appl. Pharmacol. 79 179–192 Occurrence Handle10.1016/0041-008X(85)90339-4 Occurrence Handle1:CAS:528:DyaL2MXktlegt78%3D

    Article  CAS  Google Scholar 

  • K.W. Lee B.Y.H. Liu (1982) ArticleTitleExperimental study of aerosol filtration by fibrous filters Aerosol Sci. Technol. 1 IssueID1 35–46 Occurrence Handle1:CAS:528:DyaL38XltFClt7Y%3D

    CAS  Google Scholar 

  • M.E. LeFevre F.H. Green D.D. Joel W. Laqueur (1982) ArticleTitleFrequency of black pigment in livers and spleens of coal workers: Correlation with pulmonary pathology and occupational information Hum. Pathol. 13 IssueID12 1121–1126 Occurrence Handle1:STN:280:DyaL3s%2FotFWgsg%3D%3D

    CAS  Google Scholar 

  • T.R. Lewis P.E. Morrow R.O. McClellan O.G. Raabe G.L. Kennedy B.A. Schwetz T.J. Goehl J.H. Roycroft R.S. Chhabra (1989) ArticleTitleEstablishing aerosol exposure concentrations for inhalation toxicity studies Toxicol. Appl. Pharmacol. 99 IssueID3 377–383 Occurrence Handle10.1016/0041-008X(89)90147-6 Occurrence Handle1:CAS:528:DyaL1MXlt1yns78%3D

    Article  CAS  Google Scholar 

  • N. Li C. Sioutas A. Cho D. Schmitz C. Misra J. Sempf M.Y. Wang T. Oberley J. Froines A. Nel (2003) ArticleTitleUltrafine particulate pollutants induce oxidative stress and mitochondrial damage Environ. Health Perspect. 111 IssueID4 455–460 Occurrence Handle1:CAS:528:DC%2BD3sXjtlKkurw%3D

    CAS  Google Scholar 

  • M. Lippmann (1977) Regional deposition of particles in the human respiratory tract D.H.K. Lee S. Murphy (Eds) Handbook of Physiology; Section IV, Environmental Physiology Williams and Wilkins Philadelphia 213–232

    Google Scholar 

  • D. Lison C. Lardot F. Huaux G. Zanetti B. Fubini (1997) ArticleTitleInfluence of particle surface area on the toxicity of insoluble manganese dioxide dusts Arch. Toxicol. 71 IssueID12 725–729 Occurrence Handle10.1007/s002040050453 Occurrence Handle1:CAS:528:DyaK2sXms1eqtLk%3D

    Article  CAS  Google Scholar 

  • Luther W., ed., 2004. Technological analysis. Industrial application of nanomaterials – chances and risks. Düsseldorf, Future Technologies division of VDI Technologiezentrum GmbH. Future Technologies No. 54

  • W. MacNee K. Donaldson (2003) ArticleTitleMechanism of lung injury caused by PM10 and ultrafine particles with special referance to COPD Eur. Resp. J. 21 47S–51S Occurrence Handle1:CAS:528:DC%2BD3sXktlertbk%3D

    CAS  Google Scholar 

  • W.M. Marine D. Gurr M. Jacobsen (1988) ArticleTitleClinically important respiratory effects of dust exposure and smoking in British coal miners Am. Rev. Respir. Dis. 137 106–112 Occurrence Handle1:STN:280:DyaL1c7gsVyluw%3D%3D

    CAS  Google Scholar 

  • J.C. Martin H. Danial L. Le Bouffant (1997) Short- and long-term experimental study of the toxicity of coal mine dust and of some of its constituents W.H. Walton (Eds) Inhaled Particles IV. Pergamon Press Oxford 361–370

    Google Scholar 

  • T.B. Martonen J.A. Rosati K.K. Isaacs (2005) Modeling deposition of inhaled particles L.S. Ruzer N.H. Harley (Eds) Aerosols Handbook. Measurement, Dosimetry and Health Effects CRC Press Boca Raton 113–155

    Google Scholar 

  • J.L. Mauderly R.K. Jones W.C. Griffith R.F. Henderson R.O. McClellan (1987) ArticleTitleDiesel exhaust is a pulmonary carcinogen in rats exposed chronically by inhalation Fundam. Appl. Toxicol. 9 208–221 Occurrence Handle10.1016/0272-0590(87)90044-3 Occurrence Handle1:CAS:528:DyaL2sXlsV2jsLg%3D

    Article  CAS  Google Scholar 

  • A.D. Maynard (2002) ArticleTitleExperimental determination of ultrafine TiO2 de-agglomeration in surrogate pulmonary surfactant – preliminary results Ann. Occup. Hyg. 46 IssueIDSuppl. 1 197–202

    Google Scholar 

  • A.D. Maynard (2003) ArticleTitleEstimating aerosol surface area from number and mass concentration measurements Ann. Occup. Hyg. 47 IssueID2 123–144

    Google Scholar 

  • Maynard A.D., 2004. Responsible nanotech at work. Nanotoday. A Materials Today Suppliment. Dec 2004

  • A.D. Maynard P.A. Baron (2004) Aerosols in the industrial environment L.S. Ruzer N.H. Harley (Eds) Aerosols Handbook. Measurement, Dosimetry and Health Effects CRC Press Boca Raton 225–264

    Google Scholar 

  • A.D. Maynard P.A. Baron M. Foley A.A. Shvedova E.R. Kisin V. Castranova (2004) ArticleTitleExposure to carbon nanotube material: Aerosol release during the handling of unrefined single walled carbon nanotube material J. Toxicol. Environ. Health 67 IssueID1 87–107 Occurrence Handle1:CAS:528:DC%2BD3sXps12hsbs%3D

    CAS  Google Scholar 

  • A.D. Maynard A.T. Zimmer (2002) ArticleTitleEvaluation of grinding aerosols in terms of alveolar dose: The significance of using mass, surface-area and number metrics Ann. Occup. Hyg. 46 IssueIDSuppl. 1 320–322

    Google Scholar 

  • R.O. McClellan (2000) Particle interactions with the respiratory tract P. Gehr J. Heyder (Eds) Particle-Lung Interactions Marcel Dekker Inc New York

    Google Scholar 

  • R.O. McClellan (2002) ArticleTitleSetting ambient air quality standards for particulate matter Toxicology 181 329–347 Occurrence Handle10.1016/S0300-483X(02)00459-6

    Article  Google Scholar 

  • B.G. Miller M. Jacobsen (1985) ArticleTitleDust exposure, pneumoconiosis, and mortality of coalminers Br. J. Ind. Med. 42 723–733 Occurrence Handle1:STN:280:DyaL28%2FltFartw%3D%3D

    CAS  Google Scholar 

  • F.J. Miller (1999) Dosimetry of particles in laboratory animals and humans D.E. Gardner J.D. Crapo R.O. McClellan (Eds) Toxicology of the Lung EditionNumber3 Taylor & Francis Philadelphia PA 513–556

    Google Scholar 

  • Ministry of Health, 1954. Mortality and Morbidity During the London Fog of December 1952. HMSO, London

  • C.D. Money (2003) ArticleTitleEuropean experiences in the development of approaches for the successful control of workplace health risks Ann. Occup. Hyg. 47 IssueID7 533–540 Occurrence Handle1:STN:280:DC%2BD3svmslGnuw%3D%3D

    CAS  Google Scholar 

  • N.A. Monteiro-Riviere R.J. Nemanich A.O. Inman Y.Y. Wang J.E. Riviere (2005) ArticleTitleMulti-walled carbon nanotube interactions with human epidermal kerainocytes Toxicol. Lett. 155 377–384 Occurrence Handle1:CAS:528:DC%2BD2MXkslyluw%3D%3D

    CAS  Google Scholar 

  • P. Morfeld K. Lampert H. Ziegler C. Stegmaier G. Dhom C. Piekarski (1997) ArticleTitleCoal mine dust exposure and cancer mortality in German coal miners Appl. Occup. Environ. Hyg. 12 IssueID12 909–914

    Google Scholar 

  • P.E. Morrow (1994) Mechanisms and significance of “particle overload” D.L. Dungworth J.L. Mauderly G. Oberdorster (Eds) Toxic and Carcinogenic Effects of Solid Particles in the Respiratory Tract ILSI Press Washington DC 17–25

    Google Scholar 

  • P.E. Morrow H. Muhle R. Mermelstein (1991) ArticleTitleChronic inhalation study findings as a basis for proposing a new occupational dust exposure limit J. Am. College Toxicol. 10 IssueID2 279–290

    Google Scholar 

  • B. Mossman A. Churg (1998) ArticleTitleMechanisms in the pathogenesis of asbestosis and silicosis Am. J. Respir. Crit. Care. Med 157 1666–1680 Occurrence Handle1:STN:280:DyaK1c3msVaqsA%3D%3D

    CAS  Google Scholar 

  • H. Muhle B. Bellmann O. Creutzenberg C. Dasenbrock H. Ernst R. Kilpper J.C. MacKenzie P. Morrow U. Mohr S. Takenaka (1991) ArticleTitlePulmonary response to toner upon chronic inhalation exposure in rats Fundam. Appl. Toxicol. 17 IssueID2 280–299 Occurrence Handle10.1016/0272-0590(91)90219-T Occurrence Handle1:CAS:528:DyaK3MXlt12mtLw%3D

    Article  CAS  Google Scholar 

  • W. Möller T. Hofer A. Ziesenis E. Karg J. Heyder (2002) ArticleTitleUltrafine particles cause cytoskeletal dysfunctions in macrophages Toxicol. Appl. Pharmacol. 182 IssueID3 197–207

    Google Scholar 

  • B.D. Naumann E.V. Sargent B.S. Starkman W.J. Fraser G.T. Becker G.D. Kirk (1996) ArticleTitlePerformance-based exposure control limits for pharmaceutical active ingredients Am. Ind. Hyg. Assoc. J. 57 IssueID1 33–42 Occurrence Handle1:CAS:528:DyaK28Xmtlymtg%3D%3D

    CAS  Google Scholar 

  • A. Nemmar P.H.M. Hoet B. Vanquickenborne D. Dinsdale M. Thomeer M.F. Hoylaerts H. Vanbilloen L. Mortelmans B. Nemery (2002) ArticleTitlePassage of inhaled particles into the blood circulation in humans Circulation 105 411–414 Occurrence Handle10.1161/hc0402.104118 Occurrence Handle1:CAS:528:DC%2BD38XhsVGmtLc%3D

    Article  CAS  Google Scholar 

  • A. Nemmar M.F. Hoylaerts P.H. Hoet B. Nemery (2004) ArticleTitlePossible mechanisms of the cardiovascular effects of inhaled particles: Systemic translocation and prothrombotic effects Toxicol. Lett. 149 IssueID1–3 243–253 Occurrence Handle1:CAS:528:DC%2BD2cXjtFamt7c%3D

    CAS  Google Scholar 

  • A. Nemmar H. Vanbilloen M.F. Hoylaerts P.H.M. Hoet A. Verbruggen B. Nemery (2001) ArticleTitlePassage of intratracheally instilled ultrafine particles from the lung into the systemic circulation in hamster Am. J. Respir. Crit. Care Med. 164 IssueID9 1665–1668 Occurrence Handle1:STN:280:DC%2BD38zgsVeqsQ%3D%3D

    CAS  Google Scholar 

  • K.J. Nikula M.B. Snipes E.B. Barr W.C. Griffith R.F. Henderson J.L. Mauderly (1995) ArticleTitleComparative pulmonary toxicities and carcinogenenicities of chronically inhaled diesel exhaust and carbon black in F344 rats Fundam Appl Toxicol. 25 80–94 Occurrence Handle10.1006/faat.1995.1042 Occurrence Handle1:CAS:528:DyaK2MXkvFaqtL0%3D

    Article  CAS  Google Scholar 

  • NIOSH, 1990. NIOSH testimony on the Occupational Safety and Health Administration proposed rule on health standards: Methods of compliance. U.S. Department of Health and Human Services; Public Health Service; Centers for Disease Control; National Institute for Occupational Safety and Health

  • NIOSH, 2003. Work-related lung disease surveillance report 2002. Department of Health and Human Services; Centers for Disease Control and Prevention; National Institute for Occupational Safety and Health, Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health. DHHS(NIOSH) Publication Number 2003–111

  • NIOSH, 2004. Nanotechnology & Workplace Safety and Health. National Institute for Occupational Safety and Health, DHHS (NIOSH)

  • NSET, 2004. The National Nanotechnology Initiative Stategic Plan. Nanoscale Science Engineering and Technology Subcommittee Committee on Technology National Science and Technology Council, National Science and Technology Council

  • InstitutionalAuthorNameNTP (1993) Toxicology and carcinogenesis Studies of Talc (CAS N0. 14807-96-6) (Non-Abestiform) in F344/N Rats and B6C3F, Mice (Inhalation Studies) National Toxicology Program Research Triangle Park, NC

    Google Scholar 

  • E. Oberdörster (2004) ArticleTitleManufactured nanomaterials (Fullerenes, C60) induce oxidative stress in brain of juvenile largemouth bass Environ Health Perspect. 112 IssueID10 1058–1062

    Google Scholar 

  • G. Oberdörster (2000) ArticleTitleToxicology of ultrafine particles: In vivo studies Philos. Trans. Roy. Soc. Lond. Ser. A 358 IssueID1775 2719–2740

    Google Scholar 

  • G. Oberdörster R. Ferin J. Gelein S.C. Soderholm J. Finkelstein (1992) ArticleTitleRole of the alveolar macrophage in lung injury – studies with ultrafine particles Environ. Health Perspect. 97 193–199

    Google Scholar 

  • G. Oberdörster J. Ferin B.E. Lehnert (1994a) ArticleTitleCorrelation between particle-size, in-vivo particle persistence, and lung injury Environ. Health Perspect. 102 IssueIDS5 173–179

    Google Scholar 

  • G. Oberdörster J. Ferin S. Soderholm R. Gelein C. Cox R. Baggs P.E. Morrow (1994b) ArticleTitleIncreased pulmonary toxicity of inhaled ultrafine particles: Due to lung overload alone? Ann. Occup. Hyg. 38 IssueIDSuppl. 1 295–302

    Google Scholar 

  • G. Oberdörster R.M. Gelein J. Ferin B. Weiss (1995) ArticleTitleAssociation of particulate air pollution and acute mortality: Involvement of ultrafine particles? Inhal. Toxicol. 7 111–124

    Google Scholar 

  • Oberdörster G., E. Oberdörster & J. Oberdörster, 2005. Nanotoxicology:An emerging discipline evolving from studies of ultrafine particles. Environ. Health Perspect. In press Article (doi:10.1289/ehp7339 (available at http://dx.doi.org/))

  • G. Oberdörster V. Sharp V. Atudorei A. Elder R. Gelein W. Kreyling C. Cox (2004) ArticleTitleTranslocation of inhaled ultrafine particles to the brain Inhal. Toxicol. 16 IssueID6–7 437–445

    Google Scholar 

  • G. Oberdörster Z. Sharp V. Atudorei A. Elder R. Gelein A. Lunts W. Kreyling C. Cox (2002) ArticleTitleExtrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats J. Toxicol. Environ. Health Pt A 65 IssueID20 1531–1543

    Google Scholar 

  • G. Oberdörster M.J. Utell (2002) ArticleTitleUltrafine particles in the urban air: To the respiratory tract – And beyond? Environ. Health Perspect. 110 IssueID8 A440–A441

    Google Scholar 

  • G. Oberdörster Yu (1990) ArticleTitleThe carcinogenic potential of inhaled diesel exhaust: A particle effect? J. Aerosol Sci. 21 S397–S401

    Google Scholar 

  • P.J. Oldershaw (2001) ArticleTitleControl banding – a practical approach to judging control methods for chemicals J. Prevent. Med. 9 IssueID4 52–58

    Google Scholar 

  • R.A. Parent (1992) Comparative Biology of the Normal Lung NumberInSeriesI CRC Press Boca Raton

    Google Scholar 

  • W.R. Parkes (Eds) (1994) Occupational Lung Disorders EditionNumber3 Butterworth-Heinemann Ltd. 892 Oxford, UK

    Google Scholar 

  • J. Peto R. Doll S.V. Howard L.J. Kinlen H.C. Lewinsohn (1977) ArticleTitleA mortality study among workers in an English asbestos factory Br. J. Ind. Med. 34 IssueID3 169–173 Occurrence Handle1:STN:280:DyaE1c%2FitVKrsg%3D%3D

    CAS  Google Scholar 

  • G.M. Piacitelli D.M. Sieber D.M. O’Brien R.T. Hughes R.A. Glaser J.D. Catalano (2001) ArticleTitleMetalworking fluid exposures in small machine shops: An overview AIHAJ 62 IssueID2 356–370 Occurrence Handle1:CAS:528:DC%2BD3MXltFeltbg%3D

    CAS  Google Scholar 

  • K.E. Pinkerton F.H.Y. Green C. Saiki V. Vallyathan C.G. Plopper V. Gopal D. Hung E.B. Bahne S.S. Lin M.G. Ménache M.B. Schenker (2000) ArticleTitleDistribution of particulate matter and tissue remodeling in the human lung Environ. Health Perspect. 108 IssueID11 1063–1069 Occurrence Handle1:STN:280:DC%2BD3M7htVWgtA%3D%3D

    CAS  Google Scholar 

  • B.A. Plogg P.J. Quinlan (Eds) (2002) Fundamentals of Industrial Hygiene National Safety Council Press USA

    Google Scholar 

  • C.A. Pope R.T. Burnett M.J. Thun E.E. Calle D. Krewski K. Ito G.D. Thurston (2002) ArticleTitleLung cancer, cardiopulmonary mortality and long term exposure to fine particulate air pollution J. Am. Med. Assoc. 287 IssueID9 1132–1141 Occurrence Handle10.1001/jama.287.9.1172 Occurrence Handle1:CAS:528:DC%2BD38XhslGgtbo%3D

    Article  CAS  Google Scholar 

  • D.W. Porter V. Castranova V.A. Robinson A.F. Hubbs R.R. Mercer J. Scabilloni T. Goldsmith D. Schwegler-Berry L. Battelli R. Washko J. Burkhart C. Piacitelli M. Whitmer W. Jones (1999) ArticleTitleAcute inflammatory reaction in rats after intratracheal instillation of material collected from a nylon flocking plant J. Toxicol. Environ. Health. A 14 IssueID57(1) 25–45

    Google Scholar 

  • O. Preining (1998) ArticleTitleThe physical nature of very, very small particles and its impact on their behavior J. Aerosol Sci. 29 481–495 Occurrence Handle1:CAS:528:DyaK1cXjslygtLs%3D

    CAS  Google Scholar 

  • Pui D.Y.H. & D. Chen, 2002. Experimental and Modeling Studies of Nanometer Aerosol Filtration., Grant No.: DOEIDE-FG02-98ER1490. Sponsored by the Department of Energy. Minneapolis MN, University of Minnesota, Particle Technology Laboratory

  • B. Ramazzini (1964) Diseases of Workers. De Morbis Artificuim The New York Academy of Medicine New York

    Google Scholar 

  • F.L. Rice R. Park L. Stayner R. Smith S. Gilbert H. Checkoway (2001) ArticleTitleCrystalline silica exposure and lung cancer mortality in diatomaceous earth industry workers: A quantitative risk assessment Occup. Environ. Med. 51 IssueID1 38–45

    Google Scholar 

  • S.N. Rogak R.C. Flagan H.V. Nguyen (1993) ArticleTitleThe mobility and structure of aerosol agglomerates Aerosol Sci. Technol. 18 IssueID1 25–47 Occurrence Handle1:CAS:528:DyaK3sXksFahtLw%3D

    CAS  Google Scholar 

  • W.N. Rom (Eds) (1998) Environmental and Occupational Medicine EditionNumber3 Lippincott-Raven Philadelphia

    Google Scholar 

  • V.E. Rose (1997) History and philosophy of industrial hygiene S.R. DiNardi (Eds) The Occupational Environment – its Evaluation and Control AIHA Press Fairfax 3–20

    Google Scholar 

  • S. Salvi A. Blomberg B. Rudell F. Kelly T. Sandström S.T. Holgate A.J. Frew (1999) ArticleTitleAcute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers Am. J. Respir. Crit. Care Med. 159 702–709 Occurrence Handle1:STN:280:DyaK1M7mtVOksQ%3D%3D

    CAS  Google Scholar 

  • C.M. Sayes J.D. Fortner W. Guo D. Lyon A.M. Boyd K.D. Ausman Y.J. Tao B. Sitharaman L.J. Wilson J.B. Hughes J.L. West & V.L. Colvin (2004) ArticleTitleThe differential cytoxocity of water-soluble fullerenes Nano Letters 4 IssueID10 881–1807 Occurrence Handle10.1021/nl0489586 Occurrence Handle1:CAS:528:DC%2BD2cXnsVahsLY%3D

    Article  CAS  Google Scholar 

  • J. Schwartz R. Morris (1995) ArticleTitleAir-pollution and hospital admissions for cardiovascular-disease in Detroit, Michigan Am. J. Epidemiol. 142 IssueID1 23–35 Occurrence Handle1:STN:280:DyaK2MzgsFajsQ%3D%3D

    CAS  Google Scholar 

  • A. Seaton W. MacNee K. Donaldson D. Godden (1995) ArticleTitleParticulate air pollution and acute health effects Lancet 345 176–178 Occurrence Handle10.1016/S0140-6736(95)90173-6 Occurrence Handle1:STN:280:DyaK2M7isVShug%3D%3D

    Article  CAS  Google Scholar 

  • J.A. Seinfeld S.N. Pandis (1998) Atmospheric Chemistry and Physics John Wiley & Son New York

    Google Scholar 

  • S.J. Sferlazza W.S. Beckett (1991) ArticleTitleThe respiratory health of welders Am. Rev. Respir. Dis. 143 IssueID5 Part 1 1134–1148 Occurrence Handle1:STN:280:DyaK3M3itFekuw%3D%3D

    CAS  Google Scholar 

  • J.P. Shi R.M. Harrison D. Evans (2001) ArticleTitleComparison of ambient particle surface area measurement by epiphaniometer and SMPS/APS Atmos. Environ. 35 6193–6200 Occurrence Handle1:CAS:528:DC%2BD3MXosVGisr8%3D

    CAS  Google Scholar 

  • A.A. Shvedova E.R. Kisin A.R. Murray V.Z. Gandelsman A.D. Maynard P.A. Baron V. Castranova (2003) ArticleTitleExposure to carbon nanotube material: Assessment of the biological effects of nanotube materials using human keratinocyte cells J. Toxicol. Environ. Health 66 IssueID20 1909–1926 Occurrence Handle1:CAS:528:DC%2BD3sXns1Gqsb0%3D

    CAS  Google Scholar 

  • S.B. Sinnott R. Andrews (2001) ArticleTitleCarbon nanotubes: Synthesis, properties, and applications Crit. Rev. Solid State Mat. Sci. 26 IssueID3 145–249 Occurrence Handle1:CAS:528:DC%2BD3MXnsFCqur4%3D

    CAS  Google Scholar 

  • H.D.C. Smythe L. Garcia-Contreras D.J. Cooney R.J. Garmise L.D. Jones A.J. Hickey (2004) Medical and pharmaceutical aerosols L.S. Ruzer N.H. Harley (Eds) Aerosols Handbook Measurement, Dosimetry and Health Effects CRC Press Boca Raton 265–289

    Google Scholar 

  • T. Sorahan L. Hamilton M. Tongeren Particlevan K. Gardiner J.M. Harrington (2001) ArticleTitleA cohort mortality study of U.K. carbon black workers Am. J. Indust. Med. 39 IssueID2 158–170 Occurrence Handle1:STN:280:DC%2BD3M3htlCisA%3D%3D

    CAS  Google Scholar 

  • K. Steenland J. Deddens L. Stayner (1998) ArticleTitleDiesel exhaust and lung cancer in the trucking industry: Exposure-response analyses and risk assessment Am. J. Ind. Med. 34 IssueID3 220–228 Occurrence Handle10.1002/(SICI)1097-0274(199809)34:3<220::AID-AJIM3>3.0.CO;2-Z Occurrence Handle1:STN:280:DyaK1czmsVWntA%3D%3D

    Article  CAS  Google Scholar 

  • V. Stone D.M. Brown N. Watt M. Wilson K. Donaldson H. Ritchie W. MacNee (2000) ArticleTitleUltrafine particle-mediated activation of macrophages: Intracellular calcium signaling and oxidative stress Inhal. Toxicol. 12 345–351 Occurrence Handle1:CAS:528:DC%2BD3cXntlCnsbk%3D

    CAS  Google Scholar 

  • W. Stopford J. Turner D. Cappellini T. Brock (2003) ArticleTitleBioaccessibility testing of cobalt compounds J. Environ. Monit. 5 675–680 Occurrence Handle10.1039/b302257a Occurrence Handle1:CAS:528:DC%2BD3sXlsl2mtbg%3D

    Article  CAS  Google Scholar 

  • M.T. Swihart (2003) ArticleTitleVapor-phase synthesis of nanoparticles Curr. Opin. Colloid Interface Sci. 8 IssueID1 127–133 Occurrence Handle10.1016/S1359-0294(03)00007-4 Occurrence Handle1:CAS:528:DC%2BD3sXksVKjtLw%3D

    Article  CAS  Google Scholar 

  • S. Takenaka E. Karg C. Roth H. Shulz A. Ziesenis U. Heinzmann P. Schramel J. Heyder (2001) ArticleTitlePulmonary and systemic distribution of inhaled ultrafine silver particles in rats Environ. Health Perspect. 109 IssueIDSuppl. 4 547–551 Occurrence Handle1:CAS:528:DC%2BD3MXmvVagtL0%3D

    CAS  Google Scholar 

  • J.H. Talbot (1966) ArticleTitleA diffraction size-frequency analyser with automatic recording of size-frequency distributions and total and respirable surface areas J. Sci. Instrum. 43 744–749 Occurrence Handle10.1088/0950-7671/43/10/318 Occurrence Handle1:CAS:528:DyaF28XkvVygsLg%3D

    Article  CAS  Google Scholar 

  • J.H. Talbot (1967) ArticleTitleAutomated dust measurement: The diffraction size-frequency analyser J. Mine Vent. Soc. S. Afr. 20 21–30

    Google Scholar 

  • L. Talbot R.K. Cheng R.W. Schefer D.R. Willis (1980) ArticleTitleThermophoresis of particles in a heated boundary layer J. Fluid Mech. 101 IssueID4 737–758

    Google Scholar 

  • InstitutionalAuthorNameThe Royal Society and The Royal Academy of Engineering (2004) Nanoscience and Nanotechnologies The Royal Society and The Royal Academy of Engineering London, UK

    Google Scholar 

  • S.S. Tinkle J.M. Antonini B.A. Rich J.R. Robert R. Salmen K. DePree E.J. Adkins (2003) ArticleTitleSkin as a route of exposure and sensitization in chronic beryllium disease Environ. Health Perspect. 111 IssueID9 1202–1208 Occurrence Handle1:CAS:528:DC%2BD3sXmsVektb4%3D Occurrence Handle10.1289/ehp.5999

    Article  CAS  Google Scholar 

  • C.L. Tran D. Buchanan R.T. Cullen A. Searl A.D. Jones K. Donaldson (2000) ArticleTitleInhalation of poorly soluble particles. II. Influence of particle surface area on inflammation and clearance Inhal. Toxicol. 12 IssueID12 1113–1126 Occurrence Handle1:CAS:528:DC%2BD3cXosFKlurg%3D

    CAS  Google Scholar 

  • Tran C.L., R.T. Cullen, D. Buchanan, A.D. Jones, B.G. Miller, A. Searl, J.M.G. Davis & K. Donaldson, 1999. Investigation and prediction of pulmonary responses to dust. Part II. In: Investigations into the Pulmonary Effects of Low Toxicity Dusts. Parts I and II. Contract Research Report 216/1999. Suffolk, UK, Health and Safety Executive, UK

  • D.W. VanOsdell B.Y.H. Liu K.L. Rubow D.Y.H. Pui (1990) ArticleTitleExperimental-study of submicrometer and ultrafine particle penetration and pressure-drop for high-efficiency filters Aerosol Sci. Technol. 12 IssueID4 911–925

    Google Scholar 

  • J.H. Vincent D. Mark B.G. Miller L. Armbruster T.L. Ogden (1990) ArticleTitleAerosol inhalability at higher windspeeds J. Aerosol Sci. 21 IssueID4 577–586

    Google Scholar 

  • H.W. Walton J.H. Vincent (1998) ArticleTitleAerosol instrumentation in occupational hygiene: An historical perspective Aerosol Sci. Tech. 28 417–438 Occurrence Handle1:CAS:528:DyaK1cXisFyjurc%3D

    CAS  Google Scholar 

  • H.C. Wang (1996) ArticleTitleComparison of thermal rebound theory with penetration measurements of nanometer particles through wire screens Aerosol Sci. Technol. 24 IssueID3 129–134 Occurrence Handle1:CAS:528:DyaK28XitVKku78%3D

    CAS  Google Scholar 

  • H.C. Wang G. Kasper (1991) ArticleTitleFiltration efficiency of nanometer-size aerosol-particles J. Aerosol. Sci. 22 IssueID1 31–41 Occurrence Handle1:CAS:528:DyaK3MXkslCisrc%3D

    CAS  Google Scholar 

  • D.B. Warheit (2004) ArticleTitleNanoparticles: Health impacts? Mater. Today 7 IssueID2 32–35 Occurrence Handle1:CAS:528:DC%2BD2cXislynsr0%3D

    CAS  Google Scholar 

  • D.B. Warheit B.R. Laurence K.L. Reed D.H. Roach G.A.M. Reynolds T.R. Webb (2004) ArticleTitleComparative pulmonary toxicity assessment of single-wall carbon nanotubesin rats Toxicol. Sci. 77 117–125 Occurrence Handle1:CAS:528:DC%2BD2cXnslKl

    CAS  Google Scholar 

  • R.M. Washko B. Day J.E. Parker R.M. Castellan K. Kreiss (2000) ArticleTitleEpidemiologic investigation of respiratory morbidity at a nylon flock plant E. Am. J. Ind. Med. 38 IssueID6 628–638 Occurrence Handle1:STN:280:DC%2BD3M%2FjvFCksg%3D%3D

    CAS  Google Scholar 

  • D.R. Webb S.E. Wilson D.E. Carter (1986) ArticleTitleComparative pulmonary toxicity of gallium arsenide, gallium(III) oxide, or arsenic(III) oxide intratracheally instilled into rats Toxicol. Appl. Pharmacol. 82 IssueID3 405–416 Occurrence Handle10.1016/0041-008X(86)90276-0 Occurrence Handle1:CAS:528:DyaL28XhsVemsr4%3D

    Article  CAS  Google Scholar 

  • K.T. Whitby (1978) ArticleTitleThe physical characteristics of sulfur aerosol Atmos. Environ. 12 135–159 Occurrence Handle1:CAS:528:DyaE1MXivVagug%3D%3D

    CAS  Google Scholar 

  • H.E. Wichmann A. Peters (2000) ArticleTitleEpidemiological evidence of the effects of ultrafine particle exposure Philos. Trans. Roy. Soc. Lond. Ser. A – Math. Phys. Eng. Sci. 358 IssueID1775 2751–2768 Occurrence Handle1:CAS:528:DC%2BD3cXoslWisrk%3D

    CAS  Google Scholar 

  • P. Wild A. Perdrix S. Romazini J.-J. Moulin F. Pellet (2000) ArticleTitleLung cancer mortality in a site producing hard metals Occup. Environ. Med. 57 568–573 Occurrence Handle10.1136/oem.57.8.568 Occurrence Handle1:CAS:528:DC%2BD3cXlvFCqsL4%3D

    Article  CAS  Google Scholar 

  • R.K. Wolff R.F. Henderson A.F. Eidson J.A. Pickrell S.J. Rothenberg F.F. Hahn (1988) ArticleTitleToxicity of gallium oxide particles following a 4-week inhalation exposure J. Appl. Toxicol. 8 IssueID3 191–199 Occurrence Handle1:CAS:528:DyaL1cXktFynurw%3D

    CAS  Google Scholar 

  • K.-S. Woo D.-R. Chen D.Y.H. Pui W.E. Wilson (2001) ArticleTitleUse of continuous measurements of integral aerosol parameters to estimate particle surface area Aerosol Sci. Tech. 34 57–65 Occurrence Handle1:CAS:528:DC%2BD3MXhtlGnu7w%3D

    CAS  Google Scholar 

  • Y. Ye D.Y.H. Pui B.Y.H. Liu S. Opiolka S. Blumhorst H. Fissan (1991) ArticleTitleThermophoretic effect of particle deposition on a free standing semiconductor wafer in a clean room J. Aerosol Sci. 22 IssueID1 63–72 Occurrence Handle1:CAS:528:DyaK3MXktF2lsLw%3D

    CAS  Google Scholar 

  • Q. Zhang Y. Kusaka (2000) ArticleTitleComparative injurious and proinflammatory effects of three ultrafine metals in macrophages from young and old rats Inhal. Toxicol. 12 267–273 Occurrence Handle1:CAS:528:DC%2BD3cXntlCnsLY%3D

    CAS  Google Scholar 

  • Q. Zhang Y. Kusaka K. Donaldson (2000) ArticleTitleComparative pulmonary responses caused by exposure to standard cobalt and ultrafine cobalt J. Occup. Health. 42 179–184 Occurrence Handle1:CAS:528:DC%2BD3cXmtlSksbk%3D Occurrence Handle10.1539/joh.42.179

    Article  CAS  Google Scholar 

  • Q. Zhang Y. Kusaka X. Zhu K. Sato Y. Mo T. Klutz K. Donaldson (2003) ArticleTitleComparative toxicity of standard nickel and ultrafine nickel in lung after intratracheal instillation J. Occup. Health. 45 23–30 Occurrence Handle10.1539/joh.45.23 Occurrence Handle1:CAS:528:DC%2BD3sXhvFChur8%3D

    Article  CAS  Google Scholar 

  • Q.W. Zhang Y. Kusaka K. Sato K. Nakakuki N. Kohyama K. Donaldson (1998) ArticleTitleDifferences in the extent of inflammation caused by intratracheal exposure to three ultrafine metals: Role of free radicals J. Toxicol. Environ. Health – Part a 53 IssueID6 423–438 Occurrence Handle1:CAS:528:DyaK1cXit1elurs%3D

    CAS  Google Scholar 

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  1. Project on Emerging Nanotechnologies, Woodrow Wilson International Center for Scholars, Woodrow Wilson Plaza, 1300 Pennsylvania Ave., N.W., Washington, D.C., 2004-3027

    Andrew D. Maynard & Eileen D. Kuempel

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  1. Andrew D. Maynard
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  2. Eileen D. Kuempel
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Correspondence to Andrew D. Maynard.

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Maynard, A.D., Kuempel, E.D. Airborne Nanostructured Particles and Occupational Health. J Nanopart Res 7, 587–614 (2005). https://doi.org/10.1007/s11051-005-6770-9

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