Abstract
This study was conducted to find out whether higher prevalence of females among restless legs syndrome (RLS) patients in a clinical setting is related to clinical presentation and co-morbid conditions. A total of 173 consecutive patients with idiopathic RLS were included in this study after obtaining permission from the institutional ethics committee. Their demographic data, history of RLS, associated sleep problems and family history were gathered. Severity of RLS was also measured with the help of IRLS. Results have shown that out of 173 subjects, 29.6% were males. Male subjects in this study were nearly 4 years older than females (P = 0.04). Symptoms were experienced in both legs in all subjects except 3% of females who reported involvement of one leg. Some of the patients reported symptoms in other parts of body as well! 27.5% of males and 33.6% of females reported involvement of other parts of body in addition to the legs (χ2 = 0.62; P = 0.27). Explanations of sensory symptoms e.g., “tingling”, “restlessness”, “tickling” were two times more common in females while males reported “pricking”, “just pain” and “stretching” twice as commonly as females. Severity of RLS did not differ between groups (χ2 = 1.51; P =0.67). Similarly, sleep problems were comparable across genders (88.2% males vs. 93.4% females; χ2 = 1.31; P = 0.25). Family history was comparable across genders. In conclusion, clinical presentation of RLS did not differ across genders. The observed female predominance in the RLS is not related to clinical presentation.
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Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisi J, Restless Legs Syndrome Diagnosis and Epidemiology workshop at the National Institutes of Health; International Restless Legs Syndrome Study Group. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med. 2003; 4: 101–19.
Gupta R, Lahan V, Goel D. Restless legs syndrome: common disorder but rarely diagnosed, barely treatedan Indian experience. Sleep Med. 2012; 13: 838–41.
Marin LF, Felicio AC, Santos WA, Prado LB, Prado GF. Clinical correlates of the restless legs syndrome. Arq. Neuropsiquiatr. 2012; 70: 529–31.
Tison F, Crochard A, Léger D, Bouée S, Lainey E, El Hasnaoui A. Epidemiology of restless legs syndrome in French adults: a nationwide survey: the INSTANT Study. Neurology. 2005; 65: 239–46.
Manconi M, Ulfberg J, Berger K et al. When gender matters: restless legs syndrome. Report of “RLS and woman” workshop endorsed by the European RLS study group. Sleep Med. Rev. 2012; 16: 297–307.
Winkelman JW, Finn L, Young T. Prevalence and correlates of restless legs syndrome symptoms in the Wisconsin Sleep Cohort. Sleep Med. 2006; 7: 545–52.
Erer S, Karli N, Zarifoglu M, Ozcakir A, Yildiz D. The prevalence and clinical features of restless legs syndrome: a door to door population study in Orhangazi, Bursa in Turkey. Neurol. India. 2009; 57: 729–33.
Ohayon MM, O’Hara R, Vitiello MV. Epidemiology of restless legs syndrome: a synthesis of the literature. Sleep Med. Rev. 2012; 16: 283–95.
Innes KE, Selfe TK, Agarwal P. Prevalence of restless legs syndrome in North American and Western European populations: a systematic review. Sleep Med. 2011; 12: 623–34.
Bentley AJ, Rosman KD, Mitchell D. Gender differences in the presentation of subjects with restless legs syndrome. Sleep Med. 2006; 7: 37–41.
Brown LK, Dedrick DL, Doggett JW, Guido PS. Antidepressant medication use and restless legs syndrome in patients presenting with insomnia. Sleep Med. 2005; 6: 443–50.
Gupta R, Lahan V, Goel D. A study examining depression in restless legs syndrome. Asian J. Psychiatr. 2013; 6: 308–12.
Gupta R, Lahan V, Goel D. Primary headaches in restless legs syndrome patients. Ann. Indian Acad. Neurol. 2012; 15 (Suppl 1): S104–8.
Ostacoli L, Saini A, Ferini-Strambi L et al. Restless legs syndrome and its relationship with anxiety, depression, and quality of life in cancer patients undergoing chemotherapy. Qual. Life Res. 2010; 19: 531–7.
Walters AS, LeBrocq C, Dhar A et al.: International Restless Legs Syndrome Study Group. Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome. Sleep Med. 2003; 4: 121–32.
Gupta R, Lahan V, Goel D. Translation and validation of International Restless Leg Syndrome Study Group rating scale in Hindi language. Ann. Indian Acad. Neurol. 2011; 14: 257–61.
Ohayon MM, Roth T. Prevalence of restless legs syndrome and periodic limb movement disorder in the general population. J. Psychosom. Res. 2002; 53: 547–54.
Szentkiralyi A, Fendrich K, Hoffmann W, Happe S, Berger K. Socio-economic risk factors for incident restless legs syndrome in the general population. J. Sleep Res. 2012; 21: 561–8.
Nomura T, Inoue Y, Kusumi M, Oka Y, Nakashima K. Email-based epidemiological surveys on restless legs syndrome in Japan. Sleep Biol. Rhythms. 2008; 6: 139–45.
Najafi MR, Saadantia M, Saffarifard A, Keyhanian K, Davoudi V. Epidemiology of restless legs syndrome in the Iranian population. Sleep Biol. Rhythms. 2011; 9: 56–9.
Michaud M, Chabli A, Lavigne G, Montplaisir J. Arm restlessness in patients with restless legs syndrome. Mov. Disord. 2000; 15: 289–93.
Karroum EG, Golmard JL, Leu-Semenescu S, Arnulf I. Sensations in restless legs syndrome. Sleep Med. 2012; 13: 402–8.
Kerr S, McKinon W, Bentley A. Descriptors of restless legs syndrome sensations. Sleep Med. 2012; 13: 409–13.
Gemignani F, Brindani F, Vitetta F, Marbini A. Restless legs syndrome and painful neuropathy-retrospective study. A role for nociceptive deafferentation? Pain Med. 2009; 10: 1481–6.
Gemignani F, Brindani F, Vitetta F, Marbini A, Calzetti S. Restless legs syndrome in diabetic neuropathy: a frequent manifestation of small fiber neuropathy. J. Peripher. Nerv. Syst. 2007; 12: 50–3.
Nishida S, Hitsumoto A, Namba K, Usui A, Inoue Y. Persistence of secondary restless legs syndrome in a phantom limb caused by end-stage renal disease. Intern. Med. 2013; 52: 815–8.
Giummarra MJ, Bradshaw JL. The phantom of the night: restless legs syndrome in amputees. Med. Hypotheses. 2010; 74: 968–72.
Skidmore FM, Drago V, Foster PS, Heilman KM. Bilateral restless legs affecting a phantom limb, treated with dopamine agonists. J. Neurol. Neurosurg. Psychiatry. 2009; 80: 569–70.
Lim YM, Chang SE, Chung S, Kang BH, Kim KK. Small fiber function in drug naïve patients with idiopathic restless legs syndrome. J. Clin. Neurosci. 2012; 19: 702–5.
Isak B, Agan K, Ergun A et al. Where is the core of the volcano? The undetermined origin of primary restless legs syndrome. Int. J. Neurosci. 2011; 121: 130–6.
Breimhorst M, Hondrich M, Rebhorn C, May A, Birklein F. Sensory and sympathetic correlates of heat pain sensitization and habituation in men and women. Eur. J. Pain. 2012; 16: 1281–92.
Whittom S, Dauvilliers Y, Pennestri MH et al. Age-at-onset in restless legs syndrome: a clinical and poly-somnographic study. Sleep Med. 2007; 9: 54–9.
Winkelmann J, Wetter TC, Collado-Seidel V et al. Clinical characteristics and frequency of the hereditary restless legs syndrome in a population of 300 patients. Sleep. 2000; 23: 597–602.
Hanson M, Honour M, Singleton A et al. Analysis of familial and sporadic restless legs syndrome in age of onset, gender, and severity features. J. Neurol. 2004; 251: 1398–401.
Pinaud R, Tremere LA. Control of central auditory processing by a brain-generated oestrogen. Nat. Rev. Neurosci. 2012; 13: 521–7.
Cowan RL, Frederick BB, Rainey M et al. Sex differences in response to red and blue light in human primary visual cortex: a bold fMRI study. Psychiatry Res. 2000; 100: 129–38.
Picchietti D, Allen RP, Walters AS, Davidson JE, Myers A, Ferini-Strambi L. Restless legs syndrome: prevalence and impact in children and adolescents — the Peds REST study. Pediatrics. 2007; 120: 253–66.
Berger K, Luedemann J, Trenkwalder C, John U, Kessler C. Sex and the risk of restless legs syndrome in the general population. Arch. Intern. Med. 2004; 164: 196202.
Pantaleo NP, Hening WA, Allen RP, Earley CJ. Pregnancy accounts for most of the gender difference in prevalence of familial RLS. Sleep Med. 2010; 11: 310–3.
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Gupta, R., Ahmad, S., Dhar, M. et al. Clinical presentation of restless legs syndrome: Does the gender matter?. Sleep Biol. Rhythms 12, 180–186 (2014). https://doi.org/10.1111/sbr.12059
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DOI: https://doi.org/10.1111/sbr.12059