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Activity-dependent modulation of inhibition in Purkinje cells by TrkB ligands

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Abstract

In the cerebellumin vitro TrkB receptor ligands promote activity-dependent inhibitory synaptogenesis of Purkinje cells and also modulate inhibitory synaptic function. This mini review examines the roles of TrkB receptor activation by BDNF particularly in relation to activity-dependent synaptic plasticity on Purkinje cells and recent studies on the acute modulation of GABAergic synapses by BDNF.

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Authors and Affiliations

  1. Neurology Research, VA Medical Center, P3R & D15, 97239, Portland, OR, USA

    Rosemarie Drake-Baumann

  2. Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA

    Rosemarie Drake-Baumann

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  1. Rosemarie Drake-Baumann
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Correspondence to Rosemarie Drake-Baumann.

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Drake-Baumann, R. Activity-dependent modulation of inhibition in Purkinje cells by TrkB ligands. Cerebellum 5, 220–226 (2006). https://doi.org/10.1080/14734220600621344

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  • DOI: https://doi.org/10.1080/14734220600621344

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