Abstract
Purinergic signaling is a complex and evolutionarily conserved mechanism of extracellular communication involved in many physiological and pathological functions. The complexity arises from many different purine receptor subtypes and multiple endogenous purine receptor ligands (including ATP, ADP, UTP, and adenosine) which can either be directly released from neurons or glia or can arise from extracellular metabolism. Although much work has defined the distribution of purine receptors in the cerebellum and the cellular effects of purine receptor activation, relatively little is known about how and when purines are released, the role of purinergic signaling in controlling cerebellar circuit output, and the importance of purines in cerebellar motor control.
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The figures were produced by Dr. Emily Hill.
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Wall, M.J. (2023). Purinergic Signaling in the Cerebellum. In: Gruol, D.L., Koibuchi, N., Manto, M., Molinari, M., Schmahmann, J.D., Shen, Y. (eds) Essentials of Cerebellum and Cerebellar Disorders. Springer, Cham. https://doi.org/10.1007/978-3-031-15070-8_35
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DOI: https://doi.org/10.1007/978-3-031-15070-8_35
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