Abstract
A distinct non-Hodgkin’s lymphoma (NHL) entity that grow in the body cavities as lymphomatous effusions in the absence of clinically identifiable tumor masses has been defined as primary effusional lymphoma (PEL). This lymphoma characterized by distinetive morphology, immunopheno-type, genotype and association with Kaposi’s sarcoma-associated herpesvirus (KHSV)/human her-pesvirus-8 (HHV-8) infection. In this minireview, the clinico-pathological and biological characteristics of PELs are summarized.
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Knowles DM, Inghirami G, Ubriaco A, et al: Molecular genetic analysis of three AIDS-associated neoplasms of uncertain lineage demonstrates their B-cell derivation and the possible pathogenetic role of the Epstein-Barr virus. Blood 73:792–799, 1989.
Walts AE, Shintaku IP, Said JW: Diagnosis of malignant lymphoma in effusions from patients with AIDS by gene rearrangement. Am J Clin Pathol 94:170–175, 1990.
Nador RG, Cesarman E, Chadburn A, et al: Primary effusion lymphoma: a distinct clinicopathologic entity associated with the Kaposi’s sarcoma-associated herpes virus. Blood 88:645–656, 1996.
Cesarman E, Chang Y, Moore PS, et al: Kaposi’s sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N Engl J Med 332:1186–1191, 1995.
Jaffe ES, Harris NL, Diebold J, et al: World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues. A progress report. Am J Clin Pathol 111(suppl. 1):8–12, 1999.
Carbone A, Gloghini A, Vaccher E, et al: Kaposi’s sarcoma-associated herpesvirus DNA sequences in AIDS-related and AIDS-unrelated lymphomatous effusions. Br J Haematol 94:533–543, 1996.
Nador RG, Cesarman E, Knowles DM, et al: Herpes-like DNA sequences in a body-cavity-based lymphoma in an HIV-negative patient. N Engl J Med 333:943, 1996.
Ansari MQ, Dawson DB, Nador R, et al: Primary body cavity-based AIDS-related lymphomas. Am J Clin Pathol 105:221–229, 1996.
Green I, Espiritu E, Ladanyi M, et al: Primary lymphomatous effusions in AIDS: a morphological, immunophenotypic, and molecular study. Modern Pathol 8:39–45, 1995.
Matolcsy A, Nádor RG, Cesarman E, et al: Immunoglobulin VH gene mutational analysis suggest that primary effusion lymphomas derive from different stages of B cell maturation. Am J Pathol 153:1609–1614, 1998.
Gaidan G, Capello D, Cilia AM, et al: Genetic characterization of HHV-8/KSHV-positive primary effusion lymphoma reveals frequent mutations of BCL6:implications for disease pathogenesis and histogenesis. Genes Chromosomes Cancer 24:16–23, 1999.
Moor PS, Gao S-J, Dominguez G, et al: Primary characterization of a herpesvirus agent associated with Kaposi’s sarcoma. J Virol 70:549–558, 1996.
Ambroziak JA, Herndier BG, Glogau RG, et al: Herpes-like sequences in HIV-infected and uninfected Kaposi’s sarcoma patients. Science 268:582–583, 1995.
Cesarman E, Nador RG, Bai F, et al: Kaposi’s sarcoma associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi’s sarcoma and malignant lymphoma. J Virology 70:8218–8223, 1996.
Chang Y, Moore PS, Talbot SJ, et al: Cyclin encoded by KS herpesvirus. Nature 382:410, 1996.
Horenstein MG, Nador RG, Chadburn A, et al: Epstein-Barr virus latent gene expression in primary effusion lymphomas containing Kaposi’s sarcoma-associated herpesvirus/human herpesvirus-8. Blood 90:1186–1191, 1997.
Wilson JB, Bell JL, Levine AJ: Expression of Epstein-Barr virus nuclear antigen-1 induces B cell neoplasia in transgenic mice. EMBO J 15:3117–3122, 1996.
Asou HA, Said JW, Yang R, et al: Mechanisms of growth control of Kaposi’s sarcoma-associated herpes virus-associated primary effusional lymphoma cells. Blood 91:2475–2481, 1998.
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Supported by grants from the Hungarian Ministry of Culture and Education FKFP 0931/97, the Hungarian National Science Foundation OTKA T023588 and T023588 and the Ministry of Welfare ETT 365/96.
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Matolcsy, A. Primary effusional lymphoma: A new non-hodgkin’s lymphoma entity. Pathol. Oncol. Res. 5, 87–89 (1999). https://doi.org/10.1053/paor.1999.0203
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DOI: https://doi.org/10.1053/paor.1999.0203