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Folic acid-conjugated TiO2-doped mesoporous carbonaceous nanocomposites loaded with Mitoxantrone HCl for chemo-photodynamic therapy

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Abstract

Recently, porous carbons have showed great potential in many areas. In this study, TiO2-doped mesoporous carbonaceous (TiO2@C) nanoparticles were obtained by a simple one-pot hydrothermal treatment, folic acid (FA) was conjugated to TiO2@C through an amide bond, then Mitoxantrone HCl (MTX) was adsorbed onto TiO2@C-FA and a drug delivery system, TiO2@C-FA/MTX was obtained. TiO2@C-FA/MTX showed a much faster MTX release at pH 4.5 than at pH 6.0 and pH 7.4. Furthermore, compared with free MTX, this drug delivery system showed a dose-dependent cytotoxicity by varying the irradiance, and afforded higher antitumor efficacy in cultured PC3 cells in vitro. The ability of TiO2@C-FA/MTX to combine chemotherapy with photodynamic activity enhanced the cancer cell killing effect in vitro, demonstrating that TiO2@C-FA/MTX has a great potential for cancer therapy in the future.

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Authors and Affiliations

  1. School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, PR China

    Zhi Li, Ya Ou-Yang, Yang Liu, Yi-Qiu Wang, Xia-Li Zhu & Zhen-Zhong Zhang

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  1. Zhi Li
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  2. Ya Ou-Yang
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  3. Yang Liu
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  4. Yi-Qiu Wang
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  5. Xia-Li Zhu
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  6. Zhen-Zhong Zhang
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Correspondence to Zhen-Zhong Zhang.

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Li, Z., Ou-Yang, Y., Liu, Y. et al. Folic acid-conjugated TiO2-doped mesoporous carbonaceous nanocomposites loaded with Mitoxantrone HCl for chemo-photodynamic therapy. Photochem Photobiol Sci 14, 1197–1206 (2015). https://doi.org/10.1039/c5pp00097a

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