Abstract
Breast cancer is the most common cancer among women in industrialized countries. At present, X-ray mammography is the gold standard for breast imaging, but has limitations, especially when dense breasts are imaged, as typically occurs in young women. Optical imaging can non-invasively provide information on tissue composition, structure and physiology that can be beneficially exploited for breast lesion detection and identification. In the last few decades optical breast imaging has been investigated, using different geometries (projection imaging and tomography) and measurement techniques (continuous wave, frequency resolved and time resolved approaches). Also, data analysis and display varies significantly, ranging from intensity images to maps of the optical properties (absorption and scattering), tissue composition, and physiological parameters (typically blood volume and oxygenation). This paper outlines the historical evolution of optical imaging and spectroscopy of the breast, highlighting potentialities and limitations, and presents an overview of the main applications and perspectives of the field.
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J. Ferlay, D. M. Parkin, E. Steliarova-Foucher, Estimates of cancer incidence and mortality in Europe in 2008, Eur. J. Cancer, 2010, 46, 765–781.
L. Tabar, M.-F. Yen, B. Vitak, H.-H. T. Chen, R. A. Smith, S. W. Duffy, Mammography service screening and mortality in breast cancer patients: 20-year follow-up before and after introduction of screening, Lancet, 2003, 361, 1405–1410.
E. Marshall, Brawling over Mammography, Science, 2010, 327, 936–938.
T. M. Kolb, J. Lichy, J. H. Newhouse, Comparison of the performance of screening mammography, physical examination and breast US and evaluation of factors that influence them: An analysis of 27, 825 patient evaluations, Radiology, 2002, 225, 165–175.
N. Hylton, Magnetic resonance imaging of the breast: opportunities to improve breast cancer management, J. Clin. Oncol., 2005, 23, 1678–1684.
S. J. Lord, W. Lei, P. Craft, J. N. Cawson, I. Morris, S. Walleser, A. Griffiths, S. Parker, N. Houssami, A systematic review of the effectiveness of magnetic resonance imaging (MRI) as an addition to mammography and ultrasound in screening young women at high risk of breast cancer, Eur. J. Cancer, 2007, 43, 1905–1917.
M. Nothacker, V. Duda, M. Hahn, M. Warm, F. Degenhardt, H. Madjar, S. Weinbrenner, U.-S. Albert, Early detection of breast cancer: benefits and risks of supplemental breast ultrasound in asymptomatic women with mammographically dense breast tissue. A systematic review, BMC Cancer, 2009, 9, 335.
D. Wu, S. S. Gambhir, Positron emission tomography in diagnosis and management of invasive breast cancer: Current status and future perspectives, Clin. Breast Cancer, 2003, 4, S55–S63.
A. Ishimaru, Wave Propagation and Scattering in Random Media, vol. 1, Academic Press, New York, 1978.
F. Martelli, D. Contini, A. Taddeucci, G. Zaccanti, Photon migration through a turbid slab described by a model based on diffusion approximation: II. Comparison, with Monte Carlo results, Appl. Opt., 1997, 36, 4600–4612.
F. Martelli, S. Del Bianco, A. Pifferi, L. Spinelli, A. Torricelli, G. Zaccanti, Hybrid heuristic time dependent solution of the radiative transfer equation for the slab, Proc. SPIE, 2009, 7369, 73691C.
J. B. Fishkin, E. Gratton, Propagation of photon-density waves in strongly scattering media containing an absorbing semi-infinite plane bounded by a straight edge, J. Opt. Soc. Am. A, 1993, 10, 127–140.
K. Ogawa, T. Kusaka, K. Tanimoto, T. Nishida, K. Isobe, S. Itoh, Changes in Breast Hemodynamics in Breastfeeding Mothers, J. Hum. Lactation, 2008, 24, 415–421.
R. Cubeddu, C. D’Andrea, A. Pifferi, P. Taroni, A. Torricelli, G. Valentini, Effects of the menstrual cycle on the red and near-infrared optical properties of the human breast, Photochem. Photobiol., 2000, 72, 383–391.
P. Taroni, A. Bassi, D. Comelli, A. Farina, R. Cubeddu, A. Pifferi, Diffuse optical spectroscopy of breast tissue extended to 1100 nm, J. Biomed. Opt., 2009, 14, 054030.
P. Taroni, G. Danesini, A. Torricelli, A. Pifferi, L. Spinelli, R. Cubeddu, Clinical trial of time-resolved scanning optical mammography at 4 wavelengths between 683 and 975 nm, J. Biomed. Opt., 2004, 9, 464–473.
M. S. Patterson, B. Chance, B. C. Wilson, Time-resolved reflectance and transmittance for the noninvasive measurement of tissue optical properties, Appl. Opt., 1989, 28, 2331–2336.
R. C. Haskell, L. O. Svasaand, T. T. Tsay, T. C. Feng, M. S. McAdams, B. J. Tromberg, Boundary conditions for the diffusion equation in radiative transfer, J. Opt. Soc. Am. A, 1994, 11, 2727–2741.
J. R. Mourant, T. Fuselier, J. Boyer, I. J. Bigio, Predictions and measurements of scattering and absorption over broad wavelength ranges in tissue phantoms, Appl. Opt., 1997, 36, 949–957.
A. M. Nilsson, K. C. Sturesson, D. L. Liu, S. Addersson-Engels, Changes in spectral shape of tissue optical properties in conjuction with laser-induced thermotheraphy, Appl. Opt., 1998, 37, 1256–1267.
C. D’Andrea, L. Spinelli, A. Bassi, A. Giusto, D. Contini, J. Swartling, A. Torricelli, R. Cubeddu, Time-resolved spectrally constrained method for the quantification of chromophore concentrations and scattering parameters in diffusing media, Opt. Express, 2006, 5, 1888–1898.
J. Wang, S. Jiang, Z. Li, R. M. diFlorio-Alexander, R. J. Barth, P. A. Kaufman, B. W. Pogue, K. D. Paulsen, In vivo quantitative imaging of normal and cancerous breast tissue using broadband diffuse optical tomography, Med. Phys., 2010, 37, 3715–3724.
M. Cutler, Transillumination of the breast, Surg., Gynecol. Obstet., 1929, 48, 721–727.
A. Alveryd, L. Andersson, K. Aspegren, G. Balldin, N. Bjurstam, G. Edstrom, G. Fagerberg, U. Glas, O. Jarlman, S. A. Larsson, Lightscanning versus mammography for the detection of breast cancer in screening and clinical practice. A Swedish multicenter study, Cancer, 1990, 65, 1671–1677.
G. E. Geslien, J. R. Fisher, C. De Laney, Transillumination in breast cancer detection: screening failures and potential, AJR, Am. J. Roentgenol., 1985, 144, 619–622.
J. J. Gisvold, L. R. Brown, R. G. Swee, D. J. Raygor, N. Dickerson, M. K. Ranfranz, Comparison of mammography and transillumination light scanning in the detection of breast lesions, AJR, Am. J. Roentgenol., 1986, 147, 191–194.
S. Fantini, M. A. Franceschini, G. Gaida, E. Gratton, H. Jess, W. W. Mantulin, K. T. Moesta, P. M. Schlag, M. Kaschke, Frequency-domain optical mammography: Edge effect corrections, Med. Phys., 1996, 23, 149–157.
L. Götz, S. H. Heywang-Köbrunner, O. Schütz, H. Siebold, Optical mammography on preoperative patients (Optische Mammographie an praoperativen Patientinnen), Aktuel. Radiol., 1998, 8, 31–33.
E. Heffer, V. Pera, O. Schütz, H. Siebold, S. H. Heywang-Köbrunner, L. Götz, A. Heinig, S. Fantini, Near-infrared imaging of the human breast: complementing hemoglobin concentration maps with a with a color-coded display of hypoxic areas, J. Biomed. Opt., 2004, 9, 1152–1160.
D. Grosenick, K. T. Moesta, M. Möller, J. Mucke, H. Wabnitz, B. Gebauer, C. Stroszczynski, B. Wassermann, P. M. Schlag, H. Rinneberg, Time-domain scanning optical mammography: I. Recording, and assessment of mammograms of 154 patients, Phys. Med. Biol., 2005, 50, 2429–2449.
P. Taroni, A. Torricelli, L. Spinelli, A. Pifferi, F. Arpaia, G. Danesini, R. Cubeddu, Time-resolved optical mammography between 637 and 985 nm: Clinical study on the detection and identification of breast lesions, Phys. Med. Biol., 2005, 50, 2469–2488.
D. Grosenick, H. Wabnitz, K. T. Moesta, J. Mucke, P. M. Schlag, H. Rinneberg, Time-domain scanning optical mammography: II. Optical, properties and tissue parameters of 87 carcinomas, Phys. Med. Biol., 2005, 50, 2451–2468.
L. Spinelli, A. Torricelli, A. Pifferi, P. Taroni, G. Danesini, R. Cubeddu, Characterisation of female breast lesions from multi-wavelength time-resolved optical mammography, Phys. Med. Biol., 2005, 50, 2489–2502.
H. Dehghani, B. W. Pogue, P. P. Poplack, K. D. Paulsen, Multiwavelength three-dimensional near-infrared tomography of the breast: initial simulation, phantom and clinical results, Appl. Opt., 2003, 42, 135–145.
J. P. Culver, R. Choe, M. J. Holboke, L. Zublov, T. Durduran, A. Slemp, V. Ntziachristos, B. Chance, A. G. Yodh, Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: Evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging, Med. Phys., 2003, 30, 235–247.
H. Jiang, N. V. Iftimia, Y. Xu, J. A. Eggert, L. L. Fajardo, K. L. Klove, Near-infrared optical imaging of the breast with model-based reconstruction, Acad. Radiol., 2002, 9, 186–194.
J. C. Hebden, T. D. Yates, A. Gibson, N. Everdell, S. R. Arridge, D. W. Chicken, M. Douek, M. R. S. Keshtgar, Monitoring recovery after laser surgery of the breast with optical tomography: a case study, Appl. Opt., 2005, 44, 1898–1904.
X. Intes, Time-domain optical mammography SoftScan: Initial results, Acad. Radiol., 2005, 12, 934–947.
R. X. Xu, D. C. Young, J. J. Mao, S. P. Povoski, A prospective pilot clinical trial evaluating the utility of a dynamic near-infrared imaging device for characterizing suspicious breast lesions, Breast Cancer Res., 2007, 9, R88.
R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. DeMichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, A. G. Yodh, Differentiation of benign and malignant breast tumors by in vivo three-dimensional parallel-plate diffuse optical tomography, J. Biomed. Opt., 2009, 14, 024020.
F. S. Azar, K. Lee, A. Khamene, R. Choe, A. Corlu, S. D. Konecky, F. Sauer, A. G. Yodh, Standardized platform for coregistration of nonconcurrent diffuse optical and magnetic resonance breast images obtained in different geometries, J. Biomed. Opt., 2007, 12, 051902.
S. Srinivasan, C. M. Carpenter, H. R. Ghadyani, S. J. Taka, P. A. Kaufman, R. M. Diflorio-Alexander, W. A. Wells, B. W. Pogue, K. D. Paulsen, Image guided near-infrared spectroscopy of breast tissue in vivo using boundary element method, J. Biomed. Opt., 2010, 15, 061703.
Q. Fang, J. Selb, S. A. Carp, G. Boverman, E. L. Miller, D. H. Brooks, R. H. Moore, D. B. Kopans, D. A. Boas, Combined optical and X-ray tomosynthesis breast imaging, Radiology, 2011, 258, 89–97.
Q. Zhu, P. U. Hedge, A. Ricci, M. Kane, E. B. Cronin, Y. Ardeshirpour, C. Xu, A. Aguirre, S. H. Kurtzman, P. J. Deckers, S. Tannenbaum, Early-stage invasive breast cancers: Potential role of optical tomography with US localization in assisting diagnosis, Radiology, 2010, 256, 367–378.
C. Li, H. Zhao, B. Anderson, H. Jiang, Multispectral breast imaging using a ten-wavelength, 64 × 64 source/detector channels silicon photodiode-based diffuse optical tomography system, Med. Phys., 2006, 33, 627–636.
S. D. Konecky, R. Choe, A. Corlu, K. Lee, R. Wiener, S. M. Srinivas, J. R. Saffer, R. Freifelder, J. S. Karp, N. Hajjioui, F. Azar, A. G. Yodh, Comparison of diffuse optical tomography of human breast with whole-body and breast-only positron emission tomography, Med. Phys., 2008, 35, 446–455.
A. Corlu, R. Choe, T. Durduran, K. Lee, M. Schweiger, S. R. Arridge, E. M. C. Hillman, A. G. Yodh, Diffuse optical tomography with spectral constraints and wavelength optimization, Appl. Opt., 2005, 44, 2082–2093.
M. E. Eames, J. Wang, B. W. Pogue, H. Dehghani, Wavelength band optimization in spectral near-infrared optical tomography improves accuracy while reducing data acquisition and computational burden, J. Biomed. Opt., 2008, 13, 054037.
S. H. Chung, A. E. Cerussi, C. Klifa, H. M. Baek, O. Birgul, G. Gulsen, S. I. Merritt, D. Hsiang, B. J. Tromberg, In vivo water state measurements in breast cancer using broadband diffuse optical spectroscopy, Phys. Med. Biol., 2008, 53, 6713–6727.
S. Kukreti, A. Cerussi, B. Tromberg, E. Gratton, Intrinsic tumor biomarkers revealed by novel double differential spectroscopic analysis of near-infrared spectra, J. Biomed. Opt., 2007, 12, 020509.
P. Taroni, A. Pifferi, E. Salvagnini, L. Spinelli, A. Torricelli, R. Cubeddu, Seven-wavelength time-resolved optical mammography extending beyond 1000 nm for breast collagen quantification, Opt. Express, 2009, 17, 15932–15946.
Y. P. Guo, L. J. Martin, W. Hanna, D. Benerjee, N. Miller, E. Fishell, R. Khokha, N. F. Boyd, Growth factors and stromal matrix protein associated with mammographic densities, Cancer Epidemiol., Biomarkers Prev., 2001, 10, 243–248.
X. Intes, J. Ripoll, Y. Chen, S. Nioka, A. G. Yodh, B. Chance, In vivo continuous-wave optical breast imaging enhanced with Indocyanine Green, Med. Phys., 2003, 30, 1039–1047.
V. Ntziachristos, A. G. Yodh, M. Schnall, B. Chance, Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement, Proc. Natl. Acad. Sci. U. S. A., 2000, 97, 2767–2772.
A. Poellinger, S. Burock, D. Grosenick, A. Hagen, L. Lüdemann, F. Diekmann, F. Engelken, R. Macdonald, H. Rinneberg, P.-M. Schlag, Breast cancer: Early- and late-fluorescence near-infrared imaging with indocyanine green - A preliminary study, Radiology, 2011, 258, 409–416.
A. Corlu, R. Choe, T. Durduran, M. A. Rosen, M. Schweiger, S. R. Arridge, M. D. Schnall, A. G. Yodh, Three-dimensional in vivo fluorescence diffuse optical tomography of breast cancer in humans, Opt. Express, 2007, 15, 6696–6716.
S. van de Ven, A. Wiethoff, T. Nielsen, B. Brendel, M. von der Voort, R. Nachabe, M. Van der Mark, M. Van Beek, L. Bakker, L. Fels, S. Elias, P. Luijten, W. Mali, A novel fluorescent imaging agent for diffuse optical tomography of the breast: First clinical experience in patients, Mol. Imaging Biol., 2010, 12, 343–348.
D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W.-P. Chen, B. Tromberg, Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment, Proc. Natl. Acad. Sci. U. S. A., 2011, 108, 14626–14631.
M. G. Pakalniskis, W. A. Wells, M. C. Schwab, H. M. Froehlich, S. Jiang, Z. Li, T. D. Tosteson, S. P. Poplack, P. A. Kaufman, B. W. Pogue, K. D. Paulsen, Tumor angiogenesis change estimated by using diffuse optical spectroscopic tomography: demonstrated correlation in women undergoing neoadjuvant chemotherapy for invasive breast cancer?, Radiology, 2011, 259, 365–374.
H. Soliman, A. Gunasekara, M. Rycroft, J. Zubovits, R. Dent, J. Spayne, M. J. Yaffe, G. J. Czarnota, Functional imaging using diffuse optical spectroscopy of neoadjuvant chemotherapy response in women with locally advanced breast cancer, Clin. Cancer Res., 2010, 16, 2605–2614.
Q. Zhu, S. Tannenbaum, P. Hegde, M. Kane, C. Xu, S. H. Kurtzman, Noninvasive Monitoring of Breast Cancer during Neoadjuvant Chemotherapy Using Optical Tomography with Ultrasound Localization, Neoplasia, 2008, 10, 1028–1040.
N. F. Boyd, L. J. Martin, J. Stone, C. Greenberg, S. Minkin, M. J. Yaffe, Mammographic densities as a marker of human breast cancer risk and their use in chemoprevention, Curr. Oncol. Rep., 2001, 3, 314–321.
K. M. Blackmore, J. A. Knight, L. Lilge, Association between transillumination breast spectroscopy and quantitative mammographic features of the breast, Cancer Epidemiol., Biomarkers Prev., 2008, 17, 1043–1050.
S. Alowami, S. Troup, S. Al-Haddad, I. Kirkpatrick, P. H. Watson, Mammographic density is related to stroma and stromal proteoglycan expression, Breast Cancer Res., 2003, 5, R129–R135.
P. Taroni, A. Pifferi, G. Quarto, L. Spinelli, A. Torricelli, F. Abbate, A. Villa, N. Balestreri, S. Menna, E. Cassano, R. Cubeddu, Non-invasive assessment of breast cancer risk using time-resolved diffuse optical spectroscopy, J. Biomed. Opt., 2010, 15, 060501.
D. R. Leff, O. J. Warren, L. C. Enfield, A. Gibson, T. Athanasiou, D. K. Patten, J. Hebden, G. Z. Yang, A. Darzi, Diffuse optical imaging of the healthy and diseased breast: A systematic review, Breast Cancer Res. Treat., 2008, 108, 9–22.
T. Durduran, R. Choe, W. B. Baker, A. G. Yodh, Diffuse optics for tissue monitoring and tomography, Rep. Prog. Phys., 2010, 73, 076701.
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Taroni, P. Diffuse optical imaging and spectroscopy of the breast: A brief outline of history and perspectives. Photochem Photobiol Sci 11, 241–250 (2012). https://doi.org/10.1039/c1pp05230f
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DOI: https://doi.org/10.1039/c1pp05230f