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Singlet oxygen generation using a porous monolithic polymer supported photosensitizer: potential application to the photodynamic destruction of melanoma cells

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Abstract

Photogeneration of singlet oxygen (1O2) by rose bengal is improved through the use of a porous monolithic polymer (PMP) as a support, as compared to a classic gel-type resin matrix. This type of monolithic polymeric matrix can be made at a multigram scale in quantitative yields enabling the preparation of large amounts of supported photosensitizer at low cost. The singlet oxygen induced oxidation of 9,10-diphenylanthracene has been used as a benchmark reaction, and a comparative study using rose bengal in solution, entrapped within gel-type derived polymer and entrapped within a porous monolithic polymer (PMP) has been performed. The enhanced photoreactivity of the PMP-rose bengal conjugates has been utilised for the successful photodynamic therapy (PDT) of melanoma cells.

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Authors and Affiliations

  1. Departamento de Química Inorgánica y Orgánica/UAMOA, Universitat Jaume I/CSIC, Av. Sos Baynat, s/n, 12071, Castellón, Spain

    M. Isabel Burguete, Francisco Galindo, Raquel Gavara & Santiago V. Luis

  2. School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich, Norfolk, UK, NR4 7TJ

    Miguel Moreno & David A. Russell

  3. School of Biological Sciences, University of East Anglia, Norwich, Norfolk, UK, NR4 7TJ

    Paul Thomas

Authors
  1. M. Isabel Burguete
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  2. Francisco Galindo
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  3. Raquel Gavara
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  4. Santiago V. Luis
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  5. Miguel Moreno
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  6. Paul Thomas
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  7. David A. Russell
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Corresponding authors

Correspondence to Francisco Galindo or David A. Russell.

Additional information

Electronic supplementary information (ESI) available: Fig S1-S6. See DOI: 10.1039/b810921d

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Burguete, M.I., Galindo, F., Gavara, R. et al. Singlet oxygen generation using a porous monolithic polymer supported photosensitizer: potential application to the photodynamic destruction of melanoma cells. Photochem Photobiol Sci 8, 37–44 (2009). https://doi.org/10.1039/b810921d

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