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Milestones in the development of photodynamic therapy and fluorescence diagnosis

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Abstract

Many reviews on PDT have been published. This field is now so large, and embraces so many subspecialities, from laser technology and optical penetration through diffusing media to a number of medical fields including dermatology, gastroenterology, ophthalmology, blood sterilization and treatment of microbial-viral diseases, that it is impossible to cover all aspects in a single review. Here, we will concentrate on a few basic aspects, all important for the route of development leading PDT to its present state: early work on hematoporphyrin and hematoporphyrin derivative, second and third generation photosensitizers, 5-aminolevulinic acid and its derivatives, oxygen and singlet oxygen, PDT effects on cell organelles, mutagenic potential, the basis for tumour selectivity, cell cooperativity, photochemical internalization, light penetration into tissue and the significance of oxygen depletion, photobleaching of photosensitizers, optimal light sources, effects on the immune system, and, finally, future trends.

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Authors and Affiliations

  1. Department of Radiation Biology, Institute for Cancer Research, Rikshospitalet-Radiumhospitalet Medical Center, The Norwegian Radium Hospital, Montebello, N-0310, Oslo, Norway

    Asta Juzeniene & Johan Moan

  2. Department of Pathology, Institute for Cancer Research, Rikshospitalet-Radiumhospitalet Medical Center, Montebello, 0310, Oslo, Norway

    Qian Peng

  3. Institute of Physics, University of Oslo, Blindern, 0316, Oslo, Norway

    Johan Moan

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  1. Asta Juzeniene
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Juzeniene, A., Peng, Q. & Moan, J. Milestones in the development of photodynamic therapy and fluorescence diagnosis. Photochem Photobiol Sci 6, 1234–1245 (2007). https://doi.org/10.1039/b705461k

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