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c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis

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Abstract

c-Myc promotes cellular proliferation, sensitizes cells to apoptosis and prevents differentiation. It binds cyclin T1 structurally and functionally from the positive transcription elongation factor b (P-TEFb). The cyclin-dependent kinase 9 (Cdk9) in P-TEFb then phosporylates the C-terminal domain of RNA polymerase II, which is required for the transition from initiation to elongation of eukaryotic transcription. Inhibiting P-TEFb blocks the transcription of its target genes as well as cellular proliferation and apoptosis induced by c-Myc.

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Acknowledgements

We thank members of our laboratories for reagents and helpful comments on the manuscript. This work was supported by the grants from the Nora Eccles Treadwell Foundation and the NIH.

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Authors and Affiliations

  1. Departments of Medicine, Microbiology and Immunology, Rosalind Russell Medical Research Center, University of California, San Francisco, CA, USA

    Satoshi Kanazawa & B Matija Peterlin

  2. Cancer Research Institute, University of California, San Francisco, CA, USA

    Laura Soucek & Gerard Evan

  3. Department of Molecular Genetics, Nagoya City University Medical School, Nagoya, Japan

    Satoshi Kanazawa & Takashi Okamoto

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  1. Satoshi Kanazawa
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  2. Laura Soucek
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  3. Gerard Evan
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  4. Takashi Okamoto
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  5. B Matija Peterlin
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Correspondence to B Matija Peterlin.

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Kanazawa, S., Soucek, L., Evan, G. et al. c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis. Oncogene 22, 5707–5711 (2003). https://doi.org/10.1038/sj.onc.1206800

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  • DOI: https://doi.org/10.1038/sj.onc.1206800

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