Abstract
The activation of caspases is a final commitment step for apoptosis. It is now evident that signal transduction pathways involving specific protein kinases modulate the apoptotic response. Both pro-apoptotic and anti-apoptotic pathways integrate environmental cues that control the decision to undergo apoptosis. Pro- and anti-apoptotic signal pathways regulate the activation of the caspases. In this review we describe our current understanding of apoptotic signal transduction.
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Jarpe, M., Widmann, C., Knall, C. et al. Anti-apoptotic versus pro-apoptotic signal transduction: Checkpoints and stop signs along the road to death. Oncogene 17, 1475–1482 (1998). https://doi.org/10.1038/sj.onc.1202183
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DOI: https://doi.org/10.1038/sj.onc.1202183
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