Abstract
A polymorphism of a variable number tandem repeat (VNTR), that was recently found in the promoter region of the monoamine oxidase-A (MAOA) gene, was shown to be associated with its transcriptional activity. This study examined whether this functional polymorphism of the MAOA gene is associated with the risk of developing mood disorders in a Japanese sample of 161 patients with bipolar disorder, 98 with unipolar depression, and 258 controls. There was no significant genotypic or allelic association, suggesting that the functional VNTR polymorphism in the MAOA gene is unlikely to play a major role in the pathogenesis of bipolar disorder or unipolar depression. Furthermore, we found no association between the polymorphism and a history of suicide attempt.
Similar content being viewed by others
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kunugi, H., Ishida, S., Kato, T. et al. A functional polymorphism in the promoter region of monoamine oxidase-A gene and mood disorders. Mol Psychiatry 4, 393–395 (1999). https://doi.org/10.1038/sj.mp.4000558
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.mp.4000558
- Springer Nature Limited
Keywords
This article is cited by
-
MAOA variants differ in oscillatory EEG & ECG activities in response to aggression-inducing stimuli
Scientific Reports (2019)
-
MAOA Variants and Genetic Susceptibility to Major Psychiatric Disorders
Molecular Neurobiology (2016)
-
Pharmacoepigenetics of depression: no major influence of MAO-A DNA methylation on treatment response
Journal of Neural Transmission (2015)
-
Monoamine oxidases in development
Cellular and Molecular Life Sciences (2013)
-
Association of the MAOA promoter uVNTR polymorphism with suicide attempts in patients with major depressive disorder
BMC Medical Genetics (2011)