Abstract
Genetic association studies have linked suicide behavior with genes encoding transporters of monoamine. Variants in the vesicular monoamine transporter 1 (VMAT1) have been previously shown to be associated with several psychiatric disorders including schizophrenia and bipolar disorder. However, their association with suicide behavior has not been explored. In the present study, we genotyped three single-nucleotide polymorphisms (rs2270637, rs1390938, and rs2279709) within this gene in 100 individuals who attempted suicide, 236 suicide victims, and 300 control subjects without any history of psychiatric disorders or suicide ideation. We demonstrated no difference in genotype, allele, or haplotype frequencies of theses single-nucleotide polymorphisms between the study groups. Consequently, contribution of VMAT1 in risk of psychiatric disorders might be independent of suicide behavior. Future studies with larger sample sizes are needed to confirm our results.
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References
Bondy B, Buettner A, Zill P (2006) Genetics of suicide. Mol Psychiatry 11:336–351
Chandley MJ, Ordway GA (2012) Noradrenergic dysfunction in depression and suicide. In: Noradrenergic dysfunction in depression and suicide
Dean A, Sullivan K, Soe M (2009) Open source epidemiologic statistics for public health, version. Updated 2009/19/09. Available from: http://www.openepi.com.(10 Nov 2010)
Edwards RH (1992) The transport of neurotransmitters into synaptic vesicles. Curr Opin Neurobiol 2:586–594
Erickson JD, Eiden LE, Hoffman BJ (1992) Expression cloning of a reserpine-sensitive vesicular monoamine transporter. Proc Natl Acad Sci U S A 89:10993–10997
Hawton K, Van Heeringen K (2009) Suicide. Lancet 373:1372–1381
Hong EP, Park JW (2012) Sample size and statistical power calculation in genetic association studies. Genomics inform 10:117–122
Lohoff FW (2010) Genetic variants in the vesicular monoamine transporter 1 (VMAT1/SLC18A1) and neuropsychiatric disorders. Methods Mol Biol 637:165–180
Lohoff FW, Dahl JP, Ferraro TN, Arnold SE, Gallinat J, Sander T, Berrettini WH (2006) Variations in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) are associated with bipolar i disorder. Neuropsychopharmacology 31:2739–2747
Lohoff FW, Weller AE, Bloch PJ, Buono RJ, Doyle GA, Ferraro TN, Berrettini WH (2008) Association between polymorphisms in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) on chromosome 8p and schizophrenia. Neuropsychobiology 57:55–60
Lohoff FW, Hodge R, Narasimhan S, Nall A, Ferraro TN, Mickey BJ, Heitzeg MM, Langenecker SA, Zubieta JK, Bogdan R, Nikolova YS, Drabant E, Hariri AR, Bevilacqua L, Goldman D, Doyle GA (2014) Functional genetic variants in the vesicular monoamine transporter 1 modulate emotion processing. Mol Psychiatry 19:129–139
Noroozi R, Ghafouri-Fard S, Omrani MD, Habibi M, Sayad A, Taheri M (2017) Association study of the vesicular monoamine transporter 1 (VMAT1) gene with autism in an Iranian population. Gene 625:10–14
Qin P, Agerbo E, Mortensen PB (2003) Suicide risk in relation to socioeconomic, demographic, psychiatric, and familial factors: a national register-based study of all suicides in Denmark, 1981-1997. Am J Psychiatry 160:765–772
Ricci LC, Wellman MM (1990) Monoamines: biochemical markers of suicide? J Clin Psychol 46:106–116
Richards M, Iijima Y, Kondo H, Shizuno T, Hori H, Arima K, Saitoh O, Kunugi H (2006) Association study of the vesicular monoamine transporter 1 (VMAT1) gene with schizophrenia in a Japanese population. Behav Brain Funct 2:39
Sutherland AM, Russell JA (2005) Issues with polymorphism analysis in sepsis. Clin Infect Dis 41:S396–S402
Vaht M, Kiive E, Veidebaum T, Harro J (2016) A functional vesicular monoamine transporter 1 (VMAT1) gene variant is associated with affect and the prevalence of anxiety, affective, and alcohol use disorders in a longitudinal population-representative birth cohort study. Int J Neuropsychopharmacol, 19
Ward LD, Kellis M (2012) HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants. Nucleic Acids Res 40:D930–D934
Yoo J, Lee Y, Kim Y, Rha SY, Kim Y (2008) SNPAnalyzer 2.0: a web-based integrated workbench for linkage disequilibrium analysis and association analysis. BMC Bioinf 9:290
Zhang K, Calabrese P, Nordborg M, Sun FZ (2002) Haplotype block structure and its applications to association studies: power and study designs. Am J Hum Genet 71:1386–1394
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This study was financially supported by grant number 10227 Shahid Beheshti University of Medical Sciences.
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This study was in compliance with ethical committee of Shahid Beheshti University of Medical Sciences(IR.SBMU. MSP.REC.1396.99).
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The study protocol was approved by the local ethic committee. Written informed consent was obtained from study participants or their guardians.
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Sayad, A., Noroozi, R., Khodamoradi, Z. et al. Association Study of VMAT1 Polymorphisms and Suicide Behavior. J Mol Neurosci 64, 485–490 (2018). https://doi.org/10.1007/s12031-018-1047-9
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DOI: https://doi.org/10.1007/s12031-018-1047-9