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Alpha synuclein is present in Lewy bodies in sporadic Parkinson's disease

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Abstract

A missense mutation in the human alpha synuclein gene was recently identified in some cases of familial Parkinson's disease (FPD). We have developed an antibody that recognizes the C-terminal 12 amino acids of the human alpha synuclein protein and have demonstrated that alpha synuclein is an abundant component of the Lewy bodies found within the degenerating neurons of patients with Parkinson's disease (PD). The presence of alpha synuclein in Lewy bodies of sporadic PD patients suggests a central role for alpha synuclein in the pathogenesis of PD.

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Authors and Affiliations

  1. Basic Neuroscience Program, National Institute of Neurological Disease and Stroke, National Institutes of Health, Building 36, Room 3D06, Bethesda, 20892-1430, MD, USA

    E Mezey & G Harta

  2. Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Building 49, Room 4A66, Bethesda, 20892-1430, MD, USA

    A M Dehejia, S F Suchy, R L Nussbaum & M H Polymeropoulos

  3. Section on Genetics, National Institute of Mental Health/National Human Genome Research Institute, National Institutes of Health, Building 36, Room 3D06, Bethesda, 10892-1430, MD, USA

    M J Brownstein

Authors
  1. E Mezey
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  2. A M Dehejia
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  3. G Harta
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  4. S F Suchy
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  5. R L Nussbaum
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  6. M J Brownstein
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  7. M H Polymeropoulos
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Corresponding author

Correspondence to M H Polymeropoulos.

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Mezey, E., Dehejia, A., Harta, G. et al. Alpha synuclein is present in Lewy bodies in sporadic Parkinson's disease. Mol Psychiatry 3, 493–499 (1998). https://doi.org/10.1038/sj.mp.4000446

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  • DOI: https://doi.org/10.1038/sj.mp.4000446

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