Abstract
DNA sequences which are complementary or ‘antisense’ to a target mRNA can inhibit expression of that mRNA's protein product. Antisense therapeutics has therefore received attention for inhibiting oncogenes in haematological malignancy, in particular in chronic myeloid leukaemia. However, it is now becoming clear that antisense therapeutics is considerably more problematic than was naively initially assumed. In this article, some of these difficulties are discussed, together with the achievements in CML so far. Considerable further research is required in order to define an optimal antisense therapeutics strategy for clinical use.
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This work was supported by the Leukaemia Research Fund of Great Britain.
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Clark, R. Antisense therapeutics in chronic myeloid leukaemia: the promise, the progress and the problems. Leukemia 14, 347–355 (2000). https://doi.org/10.1038/sj.leu.2401677
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DOI: https://doi.org/10.1038/sj.leu.2401677
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