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A new hydroxylase system in Actinomadura sp cells converting compactin to pravastatin

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Journal of Industrial Microbiology and Biotechnology

The hydroxylase in cell-free extracts of Actinomadura sp strain 2966 converts compactin to pravastatin. It requires NADPH as coenzyme and Mg2+ as cofactor; Mn2+ can partially replace Mg2+. In contrast with the inducible cytochrome P-450 system of Streptomyces carbophilus which catalyzes the same overall reaction, this constitutive hydroxylase is stimulated by ATP and ascorbic acid and is not inactivated by CO.

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Authors and Affiliations

  1. Fermentation Microbiology Laboratory, Biology Department, Massachusetts Institute of Technology, Cambridge, MA 02139, USA, , , , , , US

    Y Peng & A L Demain

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  1. Y Peng
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  2. A L Demain
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Received 22 December 1997/ Accepted in revised form 15 June 1998

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Peng, Y., Demain, A. A new hydroxylase system in Actinomadura sp cells converting compactin to pravastatin. J Ind Microbiol Biotech 20, 373–375 (1998). https://doi.org/10.1038/sj.jim.2900539

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  • DOI: https://doi.org/10.1038/sj.jim.2900539

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