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Chronotherapeutic delivery of verapamil in obese versus non-obese patients with essential hypertension

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Abstract

Background: The effect of controlled-onset, extended-release (COER) verapamil on haemodynamic parameters in obese and non-obese patients is evaluated in this analysis.

Methods: Data were pooled from three clinical trials evaluating efficacy and tolerability of COER-verapamil. Hypertensive men and women (stage I to III) were randomised to COER-verapamil (180–540 mg at bedtime) or placebo for 4–8 weeks and stratified according to body mass index (BMI-obese >28 kg/m2). Efficacy was assessed as change from baseline in blood pressure (BP), heart rate, and rate-pressure product during four time periods throughout the dosing interval. Safety and tolerability were assessed by monitoring all adverse events and changes in metabolic laboratory parameters.

Results: Reductions in all haemodynamic parameters were significantly greater following COER-verapamil compared with placebo for all time periods. The haemodynamic effects of COER-verapamil in obese (n= 166, BMI = 32.8 kg/m2) and non-obese patients (n = 115, BMI = 25.0 kg/m2) were similar. COER-verapamil was well tolerated in both subgroups, but the incidence of constipation was significantly less in obese patients (P < 0.001).

Conclusions: COER-verapamil is effective in reducing BP, heart rate, and rate-pressure product independently of BMI.

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Authors and Affiliations

  1. Section of Hypertension and Clinical Pharmacology, University of Connecticut School of Medicine, CT, USA

    WB White

  2. Department of Preventive Medicine, Rush-Presbyterian-St. Luke’s Medical Center, Chicago, IL, USA

    WJ Elliott & HR Black

  3. Biostatistics Department, Pharmanet, Princeton, NJ, USA

    MF Johnson

Authors
  1. WB White
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  2. WJ Elliott
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  3. MF Johnson
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  4. HR Black
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Additional information

This work was presented, in part, at the 100th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics, March 18, 1999, in San Antonio, Texas, USA

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White, W., Elliott, W., Johnson, M. et al. Chronotherapeutic delivery of verapamil in obese versus non-obese patients with essential hypertension. J Hum Hypertens 15, 135–141 (2001). https://doi.org/10.1038/sj.jhh.1001137

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  • DOI: https://doi.org/10.1038/sj.jhh.1001137

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