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Chemotherapy does not nullify the ability of donor lymphocyte infusions to mediate graft-versus-host reactions

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Abstract

Two patients with multiple myeloma in relapse after allogeneic BMT received donor lymphocyte infusions (DLI) but later required chemotherapy for treatment of myeloma-related complications. In both patients, recovery from chemotherapy-induced aplasia was accompanied by manifestations of graft-versus-host reactions. The first patient developed grade II acute GVHD and a complete remission which has lasted >22 months. The second patient developed grade III acute GVHD but died with co-existing GVHD and extensive extramedullary myeloma. These results demonstrate that chemotherapy does not nullify the ability of donor lymphocytes to mediate graft-versus-host reactions.

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Authors and Affiliations

  1. Division of Hematologic Malignancies, Bone Marrow Transplantation Program, Johns Hopkins Oncology Center, Baltimore, MD, USA

    EJ Fuchs, A Seber, V Altomonte, HG Braine, RL Humphrey, RJ Jones, SJ Noga, K Schepers, SK Wright & GB Vogelsang

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  1. EJ Fuchs
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  2. A Seber
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  3. V Altomonte
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  4. HG Braine
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  5. RL Humphrey
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  6. RJ Jones
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  7. SJ Noga
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  8. K Schepers
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  9. SK Wright
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  10. GB Vogelsang
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Fuchs, E., Seber, A., Altomonte, V. et al. Chemotherapy does not nullify the ability of donor lymphocyte infusions to mediate graft-versus-host reactions. Bone Marrow Transplant 22, 303–305 (1998). https://doi.org/10.1038/sj.bmt.1701323

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  • DOI: https://doi.org/10.1038/sj.bmt.1701323

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