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Clinical features and successful recovery from disseminated nocardiosis after BMT

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Abstract

Nocardiosis has rarely been described after BMT. When the doses of immunosuppressive therapy were tapered, a 46-year-old BMT recipient developed chronic graft-versus-host disease (GVHD) and immunosuppressive drugs were increased. Sixteen days later the patient developed nocardiosis diagnosed by lung biopsy. Trimethoprim/sulfamethoxazole (TMP/SMZ) was initiated but the doses were reduced because of rising creatinine levels. Skin and cerebral dissemination of nocardiosis was observed and TMP/SMZ doses were increased. After 4 months, the brain lesion was unaltered despite resolution of pulmonary lesions. Clinical improvement was observed after drainage of the brain abscess.

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Authors and Affiliations

  1. The BMT Program, Fundação Pró Sangue Hemocentro de São Paulo and Discipline of Hematology, University of São Paulo Medical School, Brazil

    CM Machado, MC Macedo, M Ostronoff, AC Silva, E Zambon, C Massumoto, DF Chamone & FL Dulley

  2. INCOR-HC Department of Pathology, University of São Paulo Medical School, Brazil

    JB Castelli

Authors
  1. CM Machado
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  2. MC Macedo
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  3. JB Castelli
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  4. M Ostronoff
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  5. AC Silva
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  6. E Zambon
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  7. C Massumoto
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  8. DF Chamone
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  9. FL Dulley
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Machado, C., Macedo, M., Castelli, J. et al. Clinical features and successful recovery from disseminated nocardiosis after BMT. Bone Marrow Transplant 19, 81–82 (1997). https://doi.org/10.1038/sj.bmt.1700616

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  • DOI: https://doi.org/10.1038/sj.bmt.1700616

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