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PANCREATIC ISLETS

There is more than one way to reach type 2 diabetes

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The molecular pathophysiology of diabetes in pancreatic islets remains largely a poorly understood ‘black box’ because of the inaccessibility of pancreatic tissue from living humans for molecular analysis. Wigger et al. now explore the transcriptional and proteomic profiles of pancreatic islet sections from people whose glucose tolerance was defined before pancreatic surgery during which a small portion of their pancreata became available for study.

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Fig. 1: An overview of human pancreas procurement and islet isolation for assays that can be deployed to create an atlas of the pancreas in health and disease.

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Authors and Affiliations

  1. Division of Endocrinology & Diabetes, Department of Pediatrics and Stanford Diabetes Research Center, Stanford School of Medicine, Stanford University, Stanford, CA, USA

    Anna L. Gloyn

  2. The Human Pancreas Atlas Program (HPAP) https://hpap.pmacs.upenn.edu/

    Anna L. Gloyn & Alvin C. Powers

  3. Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center and Vanderbilt University, Nashville, TN, USA

    Alvin C. Powers

  4. Tennessee Valley Healthcare System, Nashville, TN, USA

    Alvin C. Powers

Authors
  1. Anna L. Gloyn
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  2. Alvin C. Powers
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Correspondence to Anna L. Gloyn.

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Competing interests

A.L.G.’s spouse is an employee of Genentech and holds stock options in Roche. A.C.P. declares no conflicts of interest.

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Gloyn, A.L., Powers, A.C. There is more than one way to reach type 2 diabetes. Nat Metab 3, 894–895 (2021). https://doi.org/10.1038/s42255-021-00415-6

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  • DOI: https://doi.org/10.1038/s42255-021-00415-6

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