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MICROBIOME RESEARCH

Microbial signatures in metabolic tissues: a novel paradigm for obesity and diabetes?

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By analysing microbial profiles in three adipose tissue depots and the liver and plasma of morbidly obese individuals, a new study uncovers a unique organ-specific microbial signature, or potential internal ‘tissue microbiota’, in obese people with diabetes.

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Fig. 1: Bacterial compartmentalization in obese and diabetic individuals.

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Acknowledgements

P.D.C. is a senior research associate at Fonds de la Recherche Scientifique (FRS-FNRS), Belgium. He is supported by the Fonds Baillet Latour (Grant for Medical Research 2015), the Fondsde la Recherche Scientifique (FNRS, FRFS-WELBIO: WELBIO-CR-2019C-02R and EOS program no. 30770923).

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Authors and Affiliations

  1. UCLouvain, Université catholique de Louvain, Walloon Excellence in Life Sciences and Biotechnology (WELBIO), Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Brussels, Belgium

    Patrice D. Cani & Matthias Van Hul

Authors
  1. Patrice D. Cani
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  2. Matthias Van Hul
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Correspondence to Patrice D. Cani.

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Competing interests

P.D.C. is an inventor in patent applications related to the use of Akkermansia muciniphila and its components in the context of obesity and related disorders. P.D.C. is also a co-founder of A-Mansia Biotech SA. M.V.H. declares no conflicts of interest.

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Cani, P.D., Van Hul, M. Microbial signatures in metabolic tissues: a novel paradigm for obesity and diabetes?. Nat Metab 2, 211–212 (2020). https://doi.org/10.1038/s42255-020-0182-0

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