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MEMBRANE CHANNELS

Structures of CALHM channels revealed

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Recent studies report the first structures of two CALHM family members, describing unexpected oligomeric architecture and providing insights into the mechanism of function of CALHM channels.

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Fig. 1: Structures of CALHM1 and CALHM2.
Fig. 2: Displacment of TM1 by RuR in CALHM2.

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Authors and Affiliations

  1. Department of Physiology and Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    J. Kevin Foskett

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  1. J. Kevin Foskett
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Correspondence to J. Kevin Foskett.

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Foskett, J.K. Structures of CALHM channels revealed. Nat Struct Mol Biol 27, 227–228 (2020). https://doi.org/10.1038/s41594-020-0391-y

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