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Tau-targeting antibody therapies: too late, wrong epitope or wrong target?

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Two phase 2 studies of N-terminal tau–targeting antibody therapy fail to show clinical efficacy in progressive supranuclear palsy, despite evidence of target engagement.

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Fig. 1: Antibodies directed against tau that are currently in phase 1 or phase 2 trials in AD.

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Author information

Authors and Affiliations

  1. Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK

    Edwin Jabbari

  2. Movement Disorders Centre, UCL Queen Square Institute of Neurology, London, UK

    Edwin Jabbari

  3. Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA

    Karen E. Duff

  4. UK Dementia Research Institute, University College London, London, UK

    Karen E. Duff

Authors
  1. Edwin Jabbari
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  2. Karen E. Duff
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Corresponding authors

Correspondence to Edwin Jabbari or Karen E. Duff.

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Competing interests

E.J. was a study-site sub-investigator in the gosuranemab trial. K.E.D. is a director and scientific board member of Ceracuity.

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Jabbari, E., Duff, K.E. Tau-targeting antibody therapies: too late, wrong epitope or wrong target?. Nat Med 27, 1341–1342 (2021). https://doi.org/10.1038/s41591-021-01465-9

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