Combining organoids and decellularized intestinal scaffolds generates durable hybrid intestines that will open up new avenues for the regenerative treatment of patients with intestinal failure.
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References
Meran, L. et al. Nat. Med. https://doi.org/10.1038/s41591-020-1024-z (2020).
Massironi, S. et al. Dig. Liver Dis. 52, 253–261 (2020).
Nakamura, T. & Sato, T. Cell Mol Gastroenterol Hepatol 5, 51–60 (2017).
Barker, N. Nat. Rev. Mol. Cell Biol. 15, 19–33 (2014).
Sato, T. et al. Nature 459, 262–265 (2009).
Sato, T. et al. Gastroenterology 141, 1762–1772 (2011).
Spence, J. R. et al. Nature 470, 105–109 (2011).
Watson, C. L. et al. Nat. Med. 20, 1310–1314 (2014).
Giobbe, G. G. et al. Nat. Commun. 10, 5658 (2019).
Clevers, H. et al. Cell Stem Cell 24, 855–859 (2019).
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Fujii, M., Sugimoto, S. & Sato, T. Linking human intestinal scaffolds and organoids to combat intestinal failure. Nat Med 26, 1517–1518 (2020). https://doi.org/10.1038/s41591-020-1096-9
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DOI: https://doi.org/10.1038/s41591-020-1096-9
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