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Liver metastases inhibit immunotherapy efficacy

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Liver metastases lead to resistance to immunotherapy through the ‘siphoning’ of tumor antigen–specific CD8+ T cells into the liver, which results in a systemic ‘immune desert’ incapable of controlling tumor burden.

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Fig. 1: Proposed mechanism by which liver metastases result in resistance to immunotherapy.

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Authors and Affiliations

  1. Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Katherine E. Lindblad & Amaia Lujambio

  2. Liver Cancer Program, Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Katherine E. Lindblad & Amaia Lujambio

  3. The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Katherine E. Lindblad & Amaia Lujambio

  4. Graduate School of Biomedical Sciences at Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Katherine E. Lindblad & Amaia Lujambio

Authors
  1. Katherine E. Lindblad
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  2. Amaia Lujambio
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Correspondence to Amaia Lujambio.

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The authors declare no competing interests.

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Lindblad, K.E., Lujambio, A. Liver metastases inhibit immunotherapy efficacy. Nat Med 27, 25–27 (2021). https://doi.org/10.1038/s41591-020-01190-9

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  • DOI: https://doi.org/10.1038/s41591-020-01190-9

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