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MALARIA IMMUNITY

Experience counts in the malaria response

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A systems immunology analysis of controlled human malaria infections in Africans who were malaria experienced and Europeans who were malaria naive yields new insights into old questions of malaria immunity.

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Fig. 1: Systems analysis of CHMI in African and European volunteers.

References

  1. Moncunill, G. et al. Sci. Transl. Med. 12, eaay8924 (2020).

    Article  CAS  Google Scholar 

  2. Tran, T. M. et al. Immunity 51, 750–765.e10 (2019).

    Article  CAS  Google Scholar 

  3. de Jong, S. E. et al. Nat. Immunol. https://doi.org/10.1038/s41590-021-00911-7 (2021).

    Article  PubMed  Google Scholar 

  4. Crompton, P. D. et al. Annu. Rev. Immunol. 32, 157–187 (2014).

    Article  CAS  Google Scholar 

  5. Langhorne, J., Ndungu, F. M., Sponaas, A.-M. & Marsh, K. Nat. Immunol. 9, 725–732 (2008).

    Article  CAS  Google Scholar 

  6. Truong, K.-L. et al. Nat. Commun. 10, 2263 (2019).

    Article  Google Scholar 

  7. Teirlinck, A. C. et al. PLoS Pathog. 7, e1002389 (2011).

    Article  CAS  Google Scholar 

  8. Portugal, S. et al. Elife 4, e07218 (2015).

    Article  Google Scholar 

  9. Ishizuka, A. S. et al. Nat. Med. 22, 614–623 (2016).

    Article  CAS  Google Scholar 

  10. Zaidi, I. et al. J. Immunol. 199, 3781–3788 (2017).

    Article  CAS  Google Scholar 

  11. Tsang, J. S. et al. Trends Immunol. 41, 457–465 (2020).

    Article  CAS  Google Scholar 

  12. De Filippo, C. et al. Proc. Natl Acad. Sci. USA 107, 14691–14696 (2010).

    Article  Google Scholar 

Download references

Acknowledgements

The authors would like to thank Austin J. Athman (Visual Medical Arts, National Institute of Allergy and Infectious Diseases, National Institutes of Health) for assistance with creating the illustration in Fig. 1.

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Correspondence to Tuan M. Tran.

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Holla, P., Tran, T.M. Experience counts in the malaria response. Nat Immunol 22, 537–539 (2021). https://doi.org/10.1038/s41590-021-00917-1

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