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Reversion after replacement of mitochondrial DNA

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Matters Arising to this article was published on 16 October 2019

The Original Article was published on 30 November 2016

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Fig. 1: Reversion to a pathogenic mutation in mtDNA, in ES cell lines derived from mitochondrial replacement embryos.
Fig. 2: Effect of CSBII haplotypes on reversion in ES cell lines after mitochondrial replacement.

Data availability

Previously unpublished4 mtDNA sequence data from ES cell lines are available online (https://doi.org/10.5281/zenodo.3349761). Additional previously published data are available from the respective publications2,3. Further supporting sequence data from ref. 3 were provided to us by one of the authors (D. Egli).

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Acknowledgements

Work in the laboratory of G.H. and M.H. is funded by Wellcome (203105/Z/16/Z). G.H. is a Newcastle University Research Fellow and receives funding from the Michael J. Fox Foundation (ID: 15643).

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Authors and Affiliations

  1. Wellcome Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK

    Gavin Hudson, Yuko Takeda & Mary Herbert

  2. Newcastle Fertility Centre, Newcastle upon Tyne, UK

    Mary Herbert

Authors
  1. Gavin Hudson
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  2. Yuko Takeda
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  3. Mary Herbert
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Contributions

G.H., Y.T. and M.H. performed the analysis. G.H. and M.H. wrote the manuscript with input from Y.T.

Corresponding authors

Correspondence to Gavin Hudson or Mary Herbert.

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The authors declare no competing interests.

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Extended data figures and tables

Extended Data Table 1 mtDNA CSBII haplotypes of nuclear and mitochondrial donors
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Hudson, G., Takeda, Y. & Herbert, M. Reversion after replacement of mitochondrial DNA. Nature 574, E8–E11 (2019). https://doi.org/10.1038/s41586-019-1623-3

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