Successful, long-term treatment of articular cartilage injuries is important for the prevention of osteoarthritis but remains a major challenge. Three studies in 2022 highlight new approaches to improving articular cartilage regeneration.
Key advances
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A synthetic artificial stem cell (SASC) system, designed to mimic the secretome of mesenchymal stem cells, attenuated cartilage degeneration and improves the biomechanical properties of articular cartilage in vivo3.
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A zonal microstructured scaffold proved to be robust and mechanically stable in a large-animal model of osteochondral defects4.
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Scaffolds derived from solubilized articular cartilage extracellular matrix were able to successfully repair chondral lesions, particularly when loaded with TGFβ3 (ref. 5).
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Schäfer, N., Grässel, S. New refinements aim to optimize articular cartilage tissue engineering. Nat Rev Rheumatol 19, 66–67 (2023). https://doi.org/10.1038/s41584-022-00889-y
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DOI: https://doi.org/10.1038/s41584-022-00889-y
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