New findings implicate sodium transport in α-cell secretory dysfunction, leading to impaired counter-regulatory responses in diabetes. However, these findings also raise important questions about the tissue-specific roles of sodium transport and suggest that inhibitors of sodium transport may have potentially divergent roles in the pancreas, kidney and heart.
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J.A.L. has received consulting fees and/or speaking honorarium from Boehringer Ingelheim, Prometic, Intarcia Therapeutics, Inc., Novo Nordisk, Eli Lilly & Co, Merck and AstraZeneca, and has received operating grant support from Merck and Sanofi. D.Z.C. has received consulting fees and/or speaking honorarium from Janssen, Boehringer Ingelheim-Eli, Lilly, AstraZeneca, Merck, Sanofi and Prometic, and has received operating funds from Janssen, Boehringer Ingelheim-Eli, Lilly, AstraZeneca and Merck.
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Lovshin, J.A., Cherney, D.Z. Sodium transport in diabetes: two sides to the coin. Nat Rev Nephrol 15, 125–126 (2019). https://doi.org/10.1038/s41581-018-0106-3
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DOI: https://doi.org/10.1038/s41581-018-0106-3
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