In 2018, key studies shaped the way we think about environmental factors and their influence on the gut microbiota. These data highlight a new-found appreciation for the role of diet in modifying the gut microbiome and fortifying the intestinal barrier, which ultimately might lead to better treatments for chronic metabolic diseases.
Key advances
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Using a high-fibre diet to target short-chain fatty acid producers in the gut microbiota could assist type 2 diabetes management2.
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Defects in the mucous layer of mice fed a Western-style diet are mediated by gut bacteria and can be rescued by faecal microbiota transplant from chow-fed mice or by prebiotic or probiotic treatment4.
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Environmental factors such as sharing a household play a major part in shaping microbiome composition, with a relatively minor contribution by host genetics7.
Change history
25 March 2019
In the version of this article published online and in print, the intestinal epithelial barrier depicted in Fig. 1 was drawn incorrectly with the cells oriented in the wrong direction. This error has been corrected for the HTML and PDF versions of the article.
References
Gilbert, J. A. et al. Current understanding of the human microbiome. Nat. Med. 24, 392–400 (2018).
Zhao, L. et al. Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes. Science 359, 1151–1156 (2018).
Cani, P. D. et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56, 1761–1772 (2007).
Schroeder, B. O. et al. Bifidobacteria or fiber protects against diet-induced microbiota-mediated colonic mucus deterioration. Cell Host Microbe 23, 27–40 (2018).
Zou, J. et al. Fiber-mediated nourishment of gut microbiota protects against diet-induced obesity by restoring IL-22-mediated colonic health. Cell Host Microbe 23, 41–53 (2018).
Maier, L. et al. Extensive impact of non-antibiotic drugs on human gut bacteria. Nature 555, 623–628 (2018).
Rothschild, D. et al. Environment dominates over host genetics in shaping human gut microbiota. Nature 555, 210–215 (2018).
Goodrich, J. K. et al. Genetic determinants of the gut microbiome in UK twins. Cell Host Microbe 19, 731–743 (2016).
Zhu, W. et al. Precision editing of the gut microbiota ameliorates colitis. Nature 553, 208–211 (2018).
Christensen, L. et al. Microbial enterotypes in personalized nutrition and obesity management. Am. J. Clin. Nutr. 108, 645–651 (2018).
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The author has previously received travel support and honoraria from Beneo GmbH.
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Reimer, R.A. Establishing the role of diet in the microbiota–disease axis. Nat Rev Gastroenterol Hepatol 16, 86–87 (2019). https://doi.org/10.1038/s41575-018-0093-7
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DOI: https://doi.org/10.1038/s41575-018-0093-7
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