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Condensing and constraining WNT by TGF-β

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TGF-β can antagonise or cooperate with WNT signalling, yet it is still unclear what mechanisms integrate the outcomes of these conserved pathways. A new study now reports that the formation of biomolecular condensates, dependent on the DACT1 protein, provides the spatial segregation needed for TGF-β to constrain WNT signalling.

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Fig. 1: Activation of canonical WNT and TGF-β receptors lead to distinct, but integrated downstream signalling pathways.

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Authors and Affiliations

  1. Department of Pathology, Yale University School of Medicine, New Haven, CT, USA

    Kiran D. Patel & Don X. Nguyen

  2. Yale Cancer Center, Yale University School of Medicine, New Haven, CT, USA

    Don X. Nguyen

  3. Department of Medicine (Medical Oncology), Yale University School of Medicine, New Haven, CT, USA

    Don X. Nguyen

Authors
  1. Kiran D. Patel
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  2. Don X. Nguyen
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Correspondence to Don X. Nguyen.

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Competing interests

D.X.N. has received research support from AstraZeneca, Inc.

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Patel, K.D., Nguyen, D.X. Condensing and constraining WNT by TGF-β. Nat Cell Biol 23, 213–214 (2021). https://doi.org/10.1038/s41556-021-00649-2

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