Abstract
Background:
Controversial data on the association of single-nucleotide polymorphisms (SNPs, rs3787016G>A and rs10773338G>A) in long non-coding RNA (lncRNA) with prostate cancer risk were emerged. Considering possible genetic differences among populations, we conducted the present study to clarify these discrepancies and re-validate these results in an eastern Chinese population and thus provide clues for new therapeutic targets of prostate cancer.
Methods:
Genotypes of these two SNPs from 1015 ethnic Han Chinese patients with prostate cancer and 1032 cancer-free controls were determined by Taqman assays. Logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for risk associations.
Results:
The association of rs3787016 A variant genotypes with a significantly higher prostate cancer risk were found (adjusted OR=1.418, 95% CI=1.090–1.844 for AA vs GG). Stratification analysis indicated that the risk of rs3787016 variant AG/AA genotypes was more evident in younger subjects, ever smoking, patients with Gleason score ⩾7(4+3) and highly aggressive status. All these risks were not present for rs10773338G>A.
Conclusions:
These findings suggested that lncRNA SNPs may contribute to prostate cancer risk in an eastern Chinese population. Larger and well-designed studies with different ethnic populations are warranted to validate our findings.
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Acknowledgements
Financial support for our study from the National Natural Science Foundation of China (Grant number: 81302213), 985-III Cancer Research Project at Fudan University (Grant number: 985III-YFX0102) and Hospital-level fund at Fudan University Shanghai Cancer Center (Grant number: YJ201206) is gratefully acknowledged.
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Cao, DL., Gu, CY., Zhu, Y. et al. Polymorphisms at long non-coding RNAs and prostate cancer risk in an eastern Chinese population. Prostate Cancer Prostatic Dis 17, 315–319 (2014). https://doi.org/10.1038/pcan.2014.34
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DOI: https://doi.org/10.1038/pcan.2014.34
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