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Applying the brakes on gene expression

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Eukaryotic messenger RNAs are degraded through a pathway that starts with the removal of the poly(A) tail. A recent study shows that cytoplasmic mRNA deadenylation in mammals occurs by the consecutive action of two distinct deadenylases and that degradation of nonsense mRNA involves the same biphasic deadenylation pathway.

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Figure 1: Incorporation of the recent results from Yamashita et al.3 into the current model of mammalian mRNA degradation pathways leads to the following scheme.

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Authors and Affiliations

  1. Institute of Cell Biology, University of Berne, Berne, Switzerland

    Oliver Mühlemann

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  1. Oliver Mühlemann
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Mühlemann, O. Applying the brakes on gene expression. Nat Struct Mol Biol 12, 1024–1025 (2005). https://doi.org/10.1038/nsmb1205-1024

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