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Beginning at the end with SUMO

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The crystal structure of a four-protein complex comprising a SUMO ligase (E3), a SUMOylated protein substrate, and the cognate SUMO-conjugating enzyme sheds new light on catalysis, specificity and SUMO-protein interactions.

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Figure 1: Nup358/RanBp2 and catalysis of RanGAP1 SUMOylation.

References

  1. Hochstrasser, M. Nat. Cell Biol. 2, E153–E157 (2000).

    Article  CAS  Google Scholar 

  2. Johnson, E.S. Annu. Rev. Biochem. 73, 355–382 (2004).

    Article  CAS  Google Scholar 

  3. Pickart, C.M. & Eddins, M.J. Biochim. Biophys. Acta 1695, 55–72 (2004).

    Article  CAS  Google Scholar 

  4. Reverter, D. & Lima, C.D. Nature 435, 687–692 (2005).

    Article  CAS  Google Scholar 

  5. Matunis, M.J., Coutavas, E. & Blobel, G. J. Cell Biol. 135, 1457–1470 (1996).

    Article  CAS  Google Scholar 

  6. Mahajan, R., Delphin, C., Guan, T., Gerace, L. & Melchior, F. Cell 88, 97–107 (1997).

    Article  CAS  Google Scholar 

  7. Sampson, D.A., Wang, M. & Matunis, M.J. J. Biol. Chem. 276, 21664–21669 (2001).

    Article  CAS  Google Scholar 

  8. Bernier-Villamor, V., Sampson, D.A., Matunis, M.J. & Lima, C.D. Cell 108, 345–356 (2002).

    Article  CAS  Google Scholar 

  9. Pichler, A., Gast, A., Seeler, J.S., Dejean, A. & Melchior, F. Cell 108, 109–120 (2002).

    Article  CAS  Google Scholar 

  10. Pichler, A., Knipscheer, P., Saitoh, H., Sixma, T.K. & Melchior, F. Nat. Struct. Mol. Biol. 11, 984–991 (2004).

    Article  CAS  Google Scholar 

  11. Tatham, M.H. et al. Nat. Struct. Mol. Biol. 12, 67–74 (2005).

    Article  CAS  Google Scholar 

  12. Song, J., Durrin, L.K., Wilkinson, T.A., Krontiris, T.G. & Chen, Y. Proc. Natl. Acad. Sci. USA 101, 14373–14378 (2004).

    Article  CAS  Google Scholar 

  13. Sievers, A., Beringer, M., Rodnina, M.V. & Wolfenden, R. Proc. Natl. Acad. Sci. USA 101, 7897–7901 (2004).

    Article  CAS  Google Scholar 

  14. Wu, P.-Y. et al. EMBO J. 22, 5241–5250 (2003).

    Article  CAS  Google Scholar 

  15. Saitoh, H., Pu, R., Cavenagh, M. & Dasso, M. Proc. Natl. Acad. Sci. USA 94, 3736–3741 (1997).

    Article  CAS  Google Scholar 

  16. Zhang, H., Saitoh, H. & Matunis, M.J. Mol. Cell. Biol. 22, 6498–6508 (2002).

    Article  CAS  Google Scholar 

  17. Macauley, M.S. et al. J. Biol. Chem. 279, 49131–49137 (2004).

    Article  CAS  Google Scholar 

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Acknowledgements

We thank C. Lima for providing Figure 1c and M. Hochstrasser for comments on the manuscript. Work in our laboratories is funded by grants from the US National Institutes of Health.

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  1. Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, 21205, Maryland, USA

    Michael J Matunis & Cecile M Pickart

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  1. Michael J Matunis
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  2. Cecile M Pickart
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Matunis, M., Pickart, C. Beginning at the end with SUMO. Nat Struct Mol Biol 12, 565–566 (2005). https://doi.org/10.1038/nsmb0705-565

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