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A parasite calcium switch and Achilles' heel revealed

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Crystal structures of a calcium-dependent protein kinase from Toxoplasma gondii uncover a unique mechanism of activation and potential avenues for selective inhibition.

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Figure 1: Comparative schematic of activation of CDPKs (as elucidated by the study by Wernimont and colleagues7) and CaMKs.
Figure 2: ARKA approach followed by Ojo and colleagues6.

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Authors and Affiliations

  1. Christian Doerig is at the Institut National de la Santé et de la Recherche Médicale (INSERM)-Ecole Polytechnique Fédérale de Lausanne (EPFL) Joint Laboratory, INSERM U609, Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.,

    Christian Doerig

  2. Oliver Billker is at The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.,

    Oliver Billker

Authors
  1. Christian Doerig
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  2. Oliver Billker
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Correspondence to Christian Doerig or Oliver Billker.

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The authors declare no competing financial interests.

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Doerig, C., Billker, O. A parasite calcium switch and Achilles' heel revealed. Nat Struct Mol Biol 17, 541–543 (2010). https://doi.org/10.1038/nsmb0510-541

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