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Closing the circle on ribonucleotide reductases

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In this issue, a wide array of structural and biochemical techniques are applied to reveal the molecular details of activity regulation in one of life's most essential enzymes, the ribonucleotide reductase.

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Figure 1: The three different classes of RNR6,7,11,20,21.
Figure 2: Schematic overview of the two modes of allosteric regulation in ribonucleotide reductases.
Figure 3: Different architectures of inactive RNR complexes.

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Acknowledgements

The author thanks Anders Liljas for help with Figure 2.

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  1. Derek T. Logan is in the Department of Biochemistry and Structural Biology at Lund University, Lund, Sweden.,

    Derek T Logan

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  1. Derek T Logan
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Correspondence to Derek T Logan.

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Logan, D. Closing the circle on ribonucleotide reductases. Nat Struct Mol Biol 18, 251–253 (2011). https://doi.org/10.1038/nsmb0311-251

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