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Designs on a curve

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The structural rules governing the curving folds of solenoid proteins, as distilled down to the level of the underlying sequence repeats, provide designers with the tools to reliably fashion new variants with tunable geometries. Bespoke leucine-rich repeat (LRR) scaffolds, as recognition proteins, can now be tailored to better fit their targets.

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Figure 1: Overview of the main steps of the design procedure applied by Baker and co-workers6.
Figure 2: Different examples of curved solenoid proteins (green ribbon) bound to globular proteins or DNA (yellow and orange surfaces).

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Authors and Affiliations

  1. and the Department of Pharmacology, J. Fernando Bazan is at Bio-Techne Corporation, Minneapolis, Minnesota, USA, University of Minnesota School of Medicine, Minneapolis, Minnesota, USA.,

    J Fernando Bazan

  2. Andrey V. Kajava is at the Centre de Recherche de Biochimie Macromoléculaire, CNRS, University of Montpellier, Montpellier, France.,

    Andrey V Kajava

Authors
  1. J Fernando Bazan
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  2. Andrey V Kajava
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Correspondence to J Fernando Bazan or Andrey V Kajava.

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The authors declare no competing financial interests.

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Bazan, J., Kajava, A. Designs on a curve. Nat Struct Mol Biol 22, 103–105 (2015). https://doi.org/10.1038/nsmb.2966

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