The structure of bi-functional thymidylate synthase-dihydrofolate reductase suggests that substrate may be channelled accross the surface of the protein between the two active sites.
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Stroud, R. An electrostatic highway. Nat Struct Mol Biol 1, 131–134 (1994). https://doi.org/10.1038/nsb0394-131
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DOI: https://doi.org/10.1038/nsb0394-131
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