Skip to main content

Advertisement

Log in

Neuroimmunology in 2017

The central nervous system: privileged by immune connections

  • Year in Review
  • Published:

From Nature Reviews Immunology

View current issue Sign up to alerts

Over the past few years, interest in the field of neuroimmunology has expanded dramatically, thanks largely to new technologies that have advanced our understanding of the intimate connections between the nervous and immune systems1. Here, we highlight key advances in 2017 that have defined new roles for microglia in brain maintenance, for cytokines as neuromodulators and for the immune system in peripheral nerve activity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: Six of the neuroimmunology research areas.

References

  1. Kipnis, J. Multifaceted interactions between adaptive immunity and the central nervous system. Science 353, 766–771 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Keren-Shaul, H. et al. A unique microglia type associated with restricting development of Alzheimer's disease. Cell 169, 1276–1290 (2017).

    Article  CAS  PubMed  Google Scholar 

  3. Dantzer, R. et al. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat. Rev. Neurosci. 9, 46–56 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Choi, G. B. et al. The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring. Science 351, 933–939 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Shin Yim, Y. et al. Reversing behavioural abnormalities in mice exposed to maternal inflammation. Nature 549, 482–487 (2017).

    Article  PubMed  Google Scholar 

  6. Chen, C. et al. IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses. Nature 542, 43–48 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Oetjen, L. K. et al. Sensory neurons co-opt classical immune signaling pathways to mediate chronic itch. Cell 171, 217–228 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Wallrapp, A. et al. The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation. Nature 549, 351–356 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Klose, C. S. N. et al. The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation. Nature 549, 282–286 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Cardoso, V. et al. Neuronal regulation of type 2 innate lymphoid cells via neuromedin U. Nature 549, 277–281 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

The authors thank A. Impagliazzo for help with the figure.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jonathan Kipnis.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

PowerPoint slides

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kipnis, J., Filiano, A. The central nervous system: privileged by immune connections. Nat Rev Immunol 18, 83–84 (2018). https://doi.org/10.1038/nri.2017.152

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nri.2017.152

  • Springer Nature Limited

This article is cited by

Navigation