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Tlx genes make an exciting choice

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A new study shows that the transcription factor Tlx3 specifies glutamatergic phenotype and suppresses GABAergic markers during spinal cord development. Understanding this process could ultimately lead to 'customized' neurons for transplantation.

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Figure 1: Results from Cheng et al.3 regarding the specification of neurotransmitter fate in later-born interneurons that reside in the most superficial lamina of the dorsal horn of the spinal cord.

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  1. Departments of Psychiatry and Neurology, Weill Medical College of Cornell University, 1300 York Avenue, New York, 10021, New York, USA

    Stewart Anderson

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  1. Stewart Anderson
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Anderson, S. Tlx genes make an exciting choice. Nat Neurosci 7, 421–422 (2004). https://doi.org/10.1038/nn0504-421

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  • DOI: https://doi.org/10.1038/nn0504-421

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