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When size matters: CHD8 in autism

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Recent models studying loss of the mouse homolog of the autism-associated gene CHD8 show altered Wnt signaling, cell fate and proliferation. How do these findings shape our understanding of this disease?

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Figure 1: Schematic overview of the genetic origin and functional impact of Chd8 and CHD8 loss in the paper by Durak et al.2 (left column), human subjects (middle column)14 and the paper by Katayama et al.3 (right column).

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Authors and Affiliations

  1. Martin W. Breuss and Joseph G. Gleeson are in the Department of Neurosciences, Howard Hughes Medical Institute, Rady Children's Institute of Genomic Medicine, University of California, San Diego, La Jolla, California, USA.,

    Martin W Breuss & Joseph G Gleeson

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  1. Martin W Breuss
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  2. Joseph G Gleeson
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Correspondence to Joseph G Gleeson.

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Breuss, M., Gleeson, J. When size matters: CHD8 in autism. Nat Neurosci 19, 1430–1432 (2016). https://doi.org/10.1038/nn.4431

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