An APP gene duplication found in French families with β-amyloidopathy suggests a link between dementia and the vasculature.
References
Rovelet-Lecrux, A. et al. Nat. Genet. 38, 24–26 (2006).
Hardy, J. Nat. Genet. 38, 11–12 (2006).
Singleton, A., Myers, A. & Hardy, J. Hum. Mol. Genet. 13, R123–R126 (2004).
Nicoll, J.A. et al. Nat. Med. 9, 448–452 (2003).
Kumar-Singh, S. et al. Am. J. Pathol. 167, 527–543 (2005).
Miyakawa, T., Shimoji, A., Kuramoto, R. & Higuchi, Y. Virchows Arch. B. Cell. Pathol. Incl. Mol. Pathol. 40, 121–129 (1982).
Hardy, J.A., Mann, D.M.A., Wester, P. & Winblad, B. Neurobiol. Aging 7, 489–502 (1986).
Falangola, M.F., Lee, S.P., Nixon, R.A., Duff, K. & Helpern, J.A. Neurochem. Res. 30, 201–205 (2005).
Cullen, K.E., Kocsi, Z. & Stone, J. Neurobiol. Aging (doi:10.1016/j.neurobiolaging.2005.10.1016).
Xu, F. et al. Proc. Natl. Acad. Sci. USA 102, 18135–18140 (2005).
Weller, R.O. et al. Am. J. Pathol. 153, 725–733 (1998).
Lambert, M.P. et al. Proc. Natl. Acad. Sci. USA 95, 6448–6453 (1998).
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Hardy, J., Cullen, K. Amyloid at the blood vessel wall. Nat Med 12, 756–757 (2006). https://doi.org/10.1038/nm0706-756
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DOI: https://doi.org/10.1038/nm0706-756
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