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Keeping blood clots at bay in sepsis

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Clearance of platelets by the liver can help counteract the dangerous blood coagulation that can occur during sepsis. The mechanism involves clearance of platelets through the liver's Ashwell receptor, which binds to platelet glycoproteins altered by sepsis-causing bacteria (pages 648–655).

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Figure 1: Eliminating platelets during sepsis.2

Kim Caesar

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Authors and Affiliations

  1. Cornelis van 't Veer and Tom van der Poll are at the Centre for Infection and Immunity Amsterdam and the Centre for Experimental and Molecular Medicine, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, Room G2-129, 1105 AZ Amsterdam, The Netherlands. c.vantveer@amc.uva.nl or t.vanderpoll@amc.uva.nl,

    Cornelis van 't Veer & Tom van der Poll

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  1. Cornelis van 't Veer
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  2. Tom van der Poll
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van 't Veer, C., van der Poll, T. Keeping blood clots at bay in sepsis. Nat Med 14, 606–608 (2008). https://doi.org/10.1038/nm0608-606

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