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Mst-1 switches between cardiac cell life and death

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Autophagy and apoptosis are ancient processes that regulate cell fate under normal and disease conditions. A new study in mice identifies mammalian Ste20-like kinase-1 (Mst-1) as a missing link that interfaces between these pathways for cell survival and death during cardiac stress (pages 1478–1488).

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Figure 1: Dual regulation of autophagy and apoptosis by Mst-1.

Katie Vicari

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Authors and Affiliations

  1. Department of Physiology, Rimpy Dhingra is at The Institute of Cardiovascular Sciences, St. Boniface Hospital Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada.,

    Rimpy Dhingra

  2. Departments of Physiology and Pharmacology and Therapeutics, Lorrie A. Kirshenbaum is at The Institute of Cardiovascular Sciences, St. Boniface Hospital Research Centre, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.,

    Lorrie A Kirshenbaum

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  1. Rimpy Dhingra
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  2. Lorrie A Kirshenbaum
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Correspondence to Lorrie A Kirshenbaum.

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The authors declare no competing financial interests.

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Dhingra, R., Kirshenbaum, L. Mst-1 switches between cardiac cell life and death. Nat Med 19, 1367–1368 (2013). https://doi.org/10.1038/nm.3371

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