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Anuclear neutrophils keep hunting

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Neutrophils release extracellular DNA traps (NETs) to capture and kill pathogens. A recent study shows that live neutrophils are simultaneously able to form NETs while crawling and phagocytosing and can even combat bacteria after loss of their nuclear DNA (pages 1386–1393).

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Figure 1: Dynamic role of NET formation in antibacterial host defense.

References

  1. Brinkmann, V. et al. Science 303, 1532–1535 (2004).

    Article  CAS  Google Scholar 

  2. Papayannopoulos, V. & Zychlinsky, A. Trends Immunol. 30, 513–521 (2009).

    Article  CAS  Google Scholar 

  3. Manzenreiter, R. et al. J. Cyst. Fibros. 11, 84–92 (2012).

    Article  CAS  Google Scholar 

  4. Bruns, S. et al. PLoS Pathog. 6, e1000873 (2010).

    Article  Google Scholar 

  5. Fuchs, T.A. et al. J. Cell Biol. 176, 231–241 (2007).

    Article  CAS  Google Scholar 

  6. Papayannopoulos, V., Metzler, K.D., Hakkim, A. & Zychlinsky, A. J. Cell Biol. 191, 677–691 (2010).

    Article  CAS  Google Scholar 

  7. Hakkim, A. et al. Nat. Chem. Biol. 7, 75–77 (2011).

    Article  CAS  Google Scholar 

  8. Yipp, B.G. et al. Nat. Med. 18, 1386–1393 (2012).

    Article  CAS  Google Scholar 

  9. Malawista, S.E., Van Blaricom, G. & Breitenstein, M.G. J. Clin. Invest. 83, 728–732 (1989).

    Article  CAS  Google Scholar 

  10. Mantovani, A., Cassatella, M.A., Costantini, C. & Jaillon, S. Nat. Rev. Immunol. 11, 519–531 (2011).

    Article  CAS  Google Scholar 

  11. Martinelli, S. et al. J. Biol. Chem. 279, 44123–44132 (2004).

    Article  CAS  Google Scholar 

  12. Laarman, A., Milder, F., van Strijp, J. & Rooijakkers, S. J. Mol. Med. (Berl.) 88, 115–120 (2010).

    Article  CAS  Google Scholar 

  13. Caudrillier, A. et al. J. Clin. Invest. 122, 2661–2671 (2012).

    Article  CAS  Google Scholar 

  14. Berends, E.T.M. et al. J. Innate Immun. 2, 576–586 (2010).

    Article  CAS  Google Scholar 

  15. Kretschmer, D. et al. Cell Host Microbe 7, 463–473 (2010).

    Article  CAS  Google Scholar 

  16. Yousefi, S. et al. Nat. Med. 14, 949–953 (2008).

    Article  CAS  Google Scholar 

  17. von Köckritz-Blickwede, M. & Nizet, V. J. Mol. Med. (Berl.) 87, 775–783 (2009).

    Article  Google Scholar 

  18. Chow, O.A. et al. Cell Host Microbe 8, 445–454 (2010).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Andreas Peschel and Dominik Hartl are at the Interfaculty Institute for Microbiology and Infection Medicine, Tübingen, University of Tübingen, Tübingen, Germany.,

    Andreas Peschel

  2. Dominik Hartl is in the Department of Pediatrics I, University of Tübingen, Tübingen, Germany.,

    Andreas Peschel & Dominik Hartl

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  1. Andreas Peschel
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  2. Dominik Hartl
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Correspondence to Dominik Hartl.

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The authors declare no competing financial interests.

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Peschel, A., Hartl, D. Anuclear neutrophils keep hunting. Nat Med 18, 1336–1338 (2012). https://doi.org/10.1038/nm.2918

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