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Tissue factor and obesity, a two-way street

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Increasing rates of obesity and obesity-associated type 2 diabetes are threatening to reverse recent gains in reducing the rates of cardiovascular and thrombotic disease. A new study in obese mice shows that tissue factor, the principal initiator of coagulation, is also promoting the development of insulin resistance and obesity (pages 1490–1497).

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Figure 1: Crosstalk between metabolism, inflammation and coagulation.

Marina Corral

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Authors and Affiliations

  1. Nan Zhang and Daniel A. Lawrence are in the Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.,

    Nan Zhang & Daniel A Lawrence

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  1. Nan Zhang
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  2. Daniel A Lawrence
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Correspondence to Daniel A Lawrence.

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Zhang, N., Lawrence, D. Tissue factor and obesity, a two-way street. Nat Med 17, 1343–1344 (2011). https://doi.org/10.1038/nm.2551

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